Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4092042..4092823 Replicon chromosome
Accession NZ_CP092042
Organism Enterobacter cloacae isolate AVS0889

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A5E1AVC8
Locus tag MBA36_RS19580 Protein ID WP_029882967.1
Coordinates 4092042..4092533 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID A0A0M7EE97
Locus tag MBA36_RS19585 Protein ID WP_013098691.1
Coordinates 4092530..4092823 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA36_RS19560 (MBA36_19560) 4087782..4088474 + 693 WP_013098687.1 response regulator -
MBA36_RS19565 (MBA36_19565) 4088573..4090708 - 2136 WP_013098688.1 ornithine decarboxylase -
MBA36_RS19570 (MBA36_19570) 4090891..4091604 + 714 WP_013098689.1 DUF554 domain-containing protein -
MBA36_RS19580 (MBA36_19580) 4092042..4092533 - 492 WP_029882967.1 GNAT family N-acetyltransferase Toxin
MBA36_RS19585 (MBA36_19585) 4092530..4092823 - 294 WP_013098691.1 DUF1778 domain-containing protein Antitoxin
MBA36_RS19590 (MBA36_19590) 4093072..4094859 - 1788 WP_013098692.1 hybrid sensor histidine kinase/response regulator -
MBA36_RS19595 (MBA36_19595) 4094856..4095488 - 633 WP_013098693.1 response regulator transcription factor -
MBA36_RS19600 (MBA36_19600) 4095664..4095978 + 315 WP_013098694.1 lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(14-88)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17629.53 Da        Isoelectric Point: 7.2653

>T235588 WP_029882967.1 NZ_CP092042:c4092533-4092042 [Enterobacter cloacae]
MISAPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQVSGASRTFVCCGNDSNVLAYYSLASSAVMTNTAPGRFRRNMPDP
IPVVVLGRLAVDQSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYLRVGFEPSPMDPMILMVTLGDLM
ASI

Download         Length: 492 bp

>T235588 NZ_LR134308:c4887217-4887035 [Pseudomonas aeruginosa]
ATGAAGTACAGCGAGTTTCGGCGCTGGTTGAAGGCTCGGGGAGTCATTTTCGAGCCTGCCAAGGGAAGCCACTTCAAGGT
TTACTACGGCGACAACCAGACGATTTTCCCCGACCATGGAGCCAAGGAAATAGGCGATGGGTTGAGGAAGAAGATAATCA
AAGACCTGGGCCTCAAGGATTGA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 11005.67 Da        Isoelectric Point: 9.8579

>AT235588 WP_013098691.1 NZ_CP092042:c4092823-4092530 [Enterobacter cloacae]
MPTANTMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPEAYQEFLARLDQAPAPN
ATLRKTMQTPAPWEREK

Download         Length: 294 bp

>AT235588 NZ_LR134308:c4887002-4886580 [Pseudomonas aeruginosa]
ATGTTTGACTATCCCGTAACGGTTCACGAGGAAGCCGGCAGCGTGTGGGTCAGCTGCGACGATGTACCTGAAATGGCGAG
CGCCGGAGATACCGTTGATGAAGCGCTGCTGGACGCTGTGGAAGGCCTAGAGTCGGCCCTGTCGCTCTATGTGGACCGGC
GGCAGTCGATCCCGCTGCCGTCGAAAGGCAAAGCGGGTCAGTCGATCGTTCGATTGCCCGCGCTCACTTCGGCCAAGATT
GCGCTGTGGAACACCATGCTGGCTCAGAACGTAGGGAAGGCGGAACTGGCTCGCCGGCTGGGAGTGAATCGCGTTCAGGT
AGACCGCCTGGTGGATCTGCTCCACGGGTCGAAGATCGAAGCGGTGGAACATGCTCTGGCGATCTTGGGCCAACGGTTGG
CTGTGACTGTCATTGCGGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AVC8

Antitoxin

Source ID Structure
AlphaFold DB A0A0M7EE97

References