Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4009010..4009670 Replicon chromosome
Accession NZ_CP092042
Organism Enterobacter cloacae isolate AVS0889

Toxin (Protein)


Gene name cptA Uniprot ID A0A5E1AGQ2
Locus tag MBA36_RS19160 Protein ID WP_023620447.1
Coordinates 4009010..4009423 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A5E1AG01
Locus tag MBA36_RS19165 Protein ID WP_013098615.1
Coordinates 4009404..4009670 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA36_RS19140 (MBA36_19140) 4005003..4006736 - 1734 WP_013098610.1 single-stranded-DNA-specific exonuclease RecJ -
MBA36_RS19145 (MBA36_19145) 4006742..4007455 - 714 WP_013098611.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MBA36_RS19150 (MBA36_19150) 4007484..4008380 - 897 WP_013098612.1 site-specific tyrosine recombinase XerD -
MBA36_RS19155 (MBA36_19155) 4008482..4009003 + 522 WP_013098613.1 flavodoxin FldB -
MBA36_RS19160 (MBA36_19160) 4009010..4009423 - 414 WP_023620447.1 protein YgfX Toxin
MBA36_RS19165 (MBA36_19165) 4009404..4009670 - 267 WP_013098615.1 FAD assembly factor SdhE Antitoxin
MBA36_RS19170 (MBA36_19170) 4009965..4010945 + 981 WP_126347811.1 tRNA-modifying protein YgfZ -
MBA36_RS19175 (MBA36_19175) 4011055..4011714 - 660 WP_003863433.1 hemolysin III family protein -
MBA36_RS19180 (MBA36_19180) 4011980..4012711 + 732 WP_013098618.1 MurR/RpiR family transcriptional regulator -
MBA36_RS19185 (MBA36_19185) 4012828..4014261 + 1434 WP_020687084.1 6-phospho-beta-glucosidase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16220.21 Da        Isoelectric Point: 10.9554

>T235587 WP_023620447.1 NZ_CP092042:c4009423-4009010 [Enterobacter cloacae]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLSSGMMLRLRQVGGGKCQHLWLAADSMDIAEWRELRRMLLQQQPTQE

Download         Length: 414 bp

>T235587 NZ_LR134308:c3612908-3612321 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGTGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAGTTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10569.05 Da        Isoelectric Point: 5.1456

>AT235587 WP_013098615.1 NZ_CP092042:c4009670-4009404 [Enterobacter cloacae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLSDEDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235587 NZ_LR134308:c3612254-3611400 [Pseudomonas aeruginosa]
GTGCCGGACGAGACGAGCGGAGAACACACGCATTTCTGGCGCGCCGCCGAACTGGGCGGCGTCGAACTGCTGCACGCGCG
CTATGTGGAGCAGCGCTTCGCGCCGCACGTGCACAGCAGCTTCGCCCTAGTCATCATCGAGCAGGGCGCGCAGCGCTTCC
GCCATCGTGGCGGCGAGCACCTAGCCCCGCTGGGCAGCATGGTGCTGATCAACCCCGACGAAGTGCACACCGGCTCCAAG
GCCCATGATGCCGGTTGGCTCTATCGCGGCTACTACCCGGAAATGGAACAGATCGACGGGATTCTCGACGAGCTGGAAAT
CCATCATGGCGGCGTGCCGCGTTTCGCCGACAGCGTGATCCACGACCAGCCCCTGGCACGCGCCTTCGTCCACTTGCACC
GCCTGCTGGCCGAGCATGCCGGCAGCCTGGAAACCCAGACCCGCTGGCGCGAGACGATGCTCGCCCTGTTCCGTCGCCAC
GCCCGCCTGCCAGAAGCGCCGAAGGCCGGGCAGGAGCCGTTGGCGGTGGCCCGCGCCCGCGAACTGCTGGCGGCGCGGTT
GCTCGATCCGCCTTCGCTGGAGGAACTGGCGGCGGCGGTCAATCTGTCCCCGTTCCATTTTGCCCGGGTCTTCCGTCGCG
CCACCGGCATGCCGCCCCACGCCTGGCTCAGACAGCGCCGCCTGGAGCAGGCCAGGGCACTGCTCAAGAGCGGCCGGGCG
CCGCTGGAGGTGGCCCTGGAGCTGGGCTTCGCCGACCAGAGCCACCTCGGTCGCCAGTTCAAGCAGGCCTACGGGGTGCC
ACCGGGTGAATACCGCTCGGCCTGCGCGCGCTCGTCCTTGACGACATACGAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5E1AGQ2

Antitoxin

Source ID Structure
AlphaFold DB A0A5E1AG01

References