Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 519454..519970 Replicon chromosome
Accession NZ_CP092042
Organism Enterobacter cloacae isolate AVS0889

Toxin (Protein)


Gene name relE Uniprot ID A0A0M7F3X9
Locus tag MBA36_RS02500 Protein ID WP_013095355.1
Coordinates 519686..519970 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID V3EXX3
Locus tag MBA36_RS02495 Protein ID WP_008501400.1
Coordinates 519454..519696 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA36_RS02480 (MBA36_02480) 515443..516183 + 741 WP_013095353.1 KDGP aldolase family protein -
MBA36_RS02485 (MBA36_02485) 516307..517446 + 1140 WP_100168201.1 lactonase family protein -
MBA36_RS02490 (MBA36_02490) 517466..519376 + 1911 WP_126347509.1 PRD domain-containing protein -
MBA36_RS02495 (MBA36_02495) 519454..519696 + 243 WP_008501400.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
MBA36_RS02500 (MBA36_02500) 519686..519970 + 285 WP_013095355.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MBA36_RS02505 (MBA36_02505) 519974..520438 - 465 WP_013095356.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MBA36_RS02510 (MBA36_02510) 520561..522699 - 2139 WP_013095357.1 anaerobic ribonucleoside-triphosphate reductase -
MBA36_RS02515 (MBA36_02515) 523073..524716 - 1644 WP_013095358.1 alpha,alpha-phosphotrehalase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-84)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-69)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10986.92 Da        Isoelectric Point: 10.4251

>T235575 WP_013095355.1 NZ_CP092042:519686-519970 [Enterobacter cloacae]
MTYELEFDPRALKEWSKLGETVKKQFKKKLAGVLVNPRIESARLHNLPDCYKIKLRSQGYRLVYQVQDNVVTVVVIAIGK
REKLTVYHDANKRL

Download         Length: 285 bp

>T235575 NZ_LR134306:c2840316-2840223 [Yersinia pseudotuberculosis]
TAAGCCTACATTAATACCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTAGACCGAATATCAGGAATCGTA
TTCGGTCTTTTTTT

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8972.37 Da        Isoelectric Point: 5.0651

>AT235575 WP_008501400.1 NZ_CP092042:519454-519696 [Enterobacter cloacae]
MATLNVRLDDKLKNEAYAVLEKLNITPTEAVRLLFQYVAETGRMPVKTVTISDSEDALIQTVRERLANPQKGIKVSLDDL

Download         Length: 243 bp

>AT235575 NZ_LR134306:2840222-2840316 [Yersinia pseudotuberculosis]
TAAAAAAAGACCGAATACGATTCCTGATATTCGGTCTAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGT
ATTAATGTAGGCTTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0M7F3X9

Antitoxin

Source ID Structure
AlphaFold DB V3EXX3

References