Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | vagCD/VapC-VagC |
| Location | 48641..49284 | Replicon | plasmid pS19 |
| Accession | NZ_CP092041 | ||
| Organism | Salmonella enterica subsp. enterica serovar Infantis strain S19 | ||
Toxin (Protein)
| Gene name | vagD | Uniprot ID | A0A5T8FJ24 |
| Locus tag | MCR19_RS22910 | Protein ID | WP_023994137.1 |
| Coordinates | 48641..49057 (-) | Length | 139 a.a. |
Antitoxin (Protein)
| Gene name | vagC | Uniprot ID | A0A5T3Q059 |
| Locus tag | MCR19_RS22915 | Protein ID | WP_023994136.1 |
| Coordinates | 49054..49284 (-) | Length | 77 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MCR19_RS22880 (MCR19_22880) | 44121..44912 | + | 792 | WP_023994142.1 | F4 (K88) fimbria minor subunit FaeH | - |
| MCR19_RS22885 (MCR19_22885) | 44940..45704 | + | 765 | WP_023994141.1 | minor fimbrial protein | - |
| MCR19_RS22890 (MCR19_22890) | 45907..46497 | + | 591 | WP_023994140.1 | hypothetical protein | - |
| MCR19_RS22895 (MCR19_22895) | 46563..46775 | + | 213 | WP_023994139.1 | FaeA/PapI family transcriptional regulator | - |
| MCR19_RS22900 (MCR19_22900) | 47036..47197 | + | 162 | WP_001816720.1 | hypothetical protein | - |
| MCR19_RS22905 (MCR19_22905) | 47223..48071 | + | 849 | WP_023994138.1 | SdiA-regulated domain-containing protein | - |
| MCR19_RS22910 (MCR19_22910) | 48641..49057 | - | 417 | WP_023994137.1 | type II toxin-antitoxin system VapC family toxin | Toxin |
| MCR19_RS22915 (MCR19_22915) | 49054..49284 | - | 231 | WP_023994136.1 | type II toxin-antitoxin system VapB family antitoxin | Antitoxin |
| MCR19_RS22920 (MCR19_22920) | 49908..50126 | + | 219 | WP_023994135.1 | type II toxin-antitoxin system antitoxin CcdA | - |
| MCR19_RS22925 (MCR19_22925) | 50128..50433 | + | 306 | WP_023994134.1 | type II toxin-antitoxin system toxin CcdB | - |
| MCR19_RS22930 (MCR19_22930) | 50435..50725 | + | 291 | WP_023994133.1 | hypothetical protein | - |
| MCR19_RS23840 | 50722..50997 | + | 276 | Protein_59 | 3'-5' exonuclease | - |
| MCR19_RS22945 (MCR19_22945) | 51068..51184 | + | 117 | Protein_60 | hypothetical protein | - |
| MCR19_RS22950 (MCR19_22950) | 51174..51889 | - | 716 | Protein_61 | transposase | - |
| MCR19_RS22955 (MCR19_22955) | 53171..53707 | + | 537 | WP_023994130.1 | fimbrial protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | faeC / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS | 1..250171 | 250171 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 139 a.a. Molecular weight: 15123.58 Da Isoelectric Point: 8.5291
>T235571 WP_023994137.1 NZ_CP092041:c49057-48641 [Salmonella enterica subsp. enterica serovar Infantis]
VKKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVNATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWGR
VKKMYMLDTNICSFIMREQPEAVLKRLEQAVLRGHRIVVSAITYSEMRFGATGPKASPRHIELVDAFCARLDAILPWDRA
AVNATTEIKVALRLAGTPIGPNDTAIAGHAIAAGAVLVTNNTREFERVPGLVLEDWGR
Download Length: 417 bp
>T235571 NZ_LR134305:c2223704-2223438 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA
Antitoxin
Download Length: 77 a.a. Molecular weight: 8650.75 Da Isoelectric Point: 4.5881
>AT235571 WP_023994136.1 NZ_CP092041:c49284-49054 [Salmonella enterica subsp. enterica serovar Infantis]
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPGFMAEREDVVSDEGRFNL
MRTVSIFKNGNNRAIRLPRDLDFDGVSELEIVREGDSIILRPVRPTWGSFAQLEKADPGFMAEREDVVSDEGRFNL
Download Length: 231 bp
>AT235571 NZ_LR134305:c2223961-2223704 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T8FJ24 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A5T3Q059 |