Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 14531..15121 Replicon plasmid pS19
Accession NZ_CP092041
Organism Salmonella enterica subsp. enterica serovar Infantis strain S19

Toxin (Protein)


Gene name pemK Uniprot ID A0A241PXU0
Locus tag MCR19_RS22705 Protein ID WP_023994178.1
Coordinates 14789..15121 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A5T3Q5H6
Locus tag MCR19_RS22700 Protein ID WP_023994179.1
Coordinates 14531..14788 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCR19_RS22680 (MCR19_22680) 10030..11055 + 1026 WP_023994180.1 IS630 family transposase -
MCR19_RS22685 (MCR19_22685) 11059..12078 - 1020 WP_223155817.1 hypothetical protein -
MCR19_RS22690 (MCR19_22690) 12218..12724 - 507 WP_223155815.1 hypothetical protein -
MCR19_RS22695 (MCR19_22695) 12835..13920 - 1086 WP_223155813.1 hypothetical protein -
MCR19_RS22700 (MCR19_22700) 14531..14788 + 258 WP_023994179.1 hypothetical protein Antitoxin
MCR19_RS22705 (MCR19_22705) 14789..15121 + 333 WP_023994178.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
MCR19_RS22710 (MCR19_22710) 15721..16326 + 606 Protein_14 IS481 family transposase -
MCR19_RS22715 (MCR19_22715) 16625..18847 - 2223 WP_023994175.1 DEAD/DEAH box helicase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - faeC / faeD / faeE / faeF / faeH / faeI / fyuA / ybtE / ybtT / ybtU / irp1 / irp2 / ybtA / ybtP / ybtQ / ybtX / ybtS 1..250171 250171
- inside IScluster/Tn - - 10018..16326 6308


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11787.54 Da        Isoelectric Point: 9.3417

>T235569 WP_023994178.1 NZ_CP092041:14789-15121 [Salmonella enterica subsp. enterica serovar Infantis]
MDRGEIWLVSLDPTAGHEQSGKRPVLIVSPASFNKFTRLPVVVPVTSGGDFARTAGFTVSLDGAGTKTTGVIRCDQPRTI
DMGARNGKRLERIPEAVVNEVLARLEAILS

Download         Length: 333 bp

>T235569 NZ_LR134305:c2165040-2164774 [Staphylococcus aureus]
ATGGATAGGTTAAATATTACGTTTTCGCCTCAAGCCTTTGCAGATTATAAGTATTTTCAGCAGAACGATAAAAAAATGGT
GAAGAAGATTAATGAGTTACTTAAAAGTATTGACAGAAATGGCGCATTGAAAGGTATAGGTAAGCCTGAAAAGTTAAAAT
CGAATCTGACTGGGTATTATAGTAGACGTATCAATCACGAACATAGATTGGTTTATAAAGTAGATGACAATCATATAAAA
ATAGCATCATGTAAATACCATTATTAA

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9374.86 Da        Isoelectric Point: 4.4354

>AT235569 WP_023994179.1 NZ_CP092041:14531-14788 [Salmonella enterica subsp. enterica serovar Infantis]
MYTTRLKKVGGSVMLAVPPAVLKTLALSTDSEVGMTIDNGCLIIEPQKRPRYSLEELLAQCDPHAEMSDEDREWMDAPAV
GKEIL

Download         Length: 258 bp

>AT235569 NZ_LR134305:c2165291-2165040 [Staphylococcus aureus]
ATGATTATTAAAAATTATTCATACGCTCGACAGAATTTAAAGGCACTTATGACAAAAGTAAATGATGATAGTGATATGGT
AACTGTAACATCTACTGATGATAAAAACGTAGTAATCATGTCAGAATCAGATTATAACTCCATGATGGAAACACTTTACC
TCCAACAGAATCCAAATAATGCTGAACACTTAGCTCAATCAATTGCAGATCTAGAACGTGGGAAAACTATAACGAAAGAT
ATAGATGTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A241PXU0

Antitoxin

Source ID Structure
AlphaFold DB A0A5T3Q5H6

References