Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4251332..4252092 Replicon chromosome
Accession NZ_CP092040
Organism Salmonella enterica subsp. enterica serovar Infantis strain S19

Toxin (Protein)


Gene name tacT Uniprot ID Q57IH1
Locus tag MCR19_RS20570 Protein ID WP_000533909.1
Coordinates 4251332..4251817 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID M7RHS4
Locus tag MCR19_RS20575 Protein ID WP_000965886.1
Coordinates 4251805..4252092 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCR19_RS20540 (4246403) 4246403..4247065 + 663 WP_000747548.1 OmpA family lipoprotein -
MCR19_RS20545 (4247284) 4247284..4248258 + 975 WP_023198076.1 glyoxylate/hydroxypyruvate reductase GhrB -
MCR19_RS20550 (4248308) 4248308..4249018 - 711 WP_000190524.1 DUF3053 domain-containing protein -
MCR19_RS20555 (4249457) 4249457..4249747 + 291 WP_000455790.1 HTH-type transcriptional regulator -
MCR19_RS20560 (4250035) 4250035..4250247 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MCR19_RS20565 (4250421) 4250421..4250960 + 540 WP_000047148.1 copper-binding periplasmic metallochaperone CueP -
MCR19_RS20570 (4251332) 4251332..4251817 - 486 WP_000533909.1 GNAT family N-acetyltransferase Toxin
MCR19_RS20575 (4251805) 4251805..4252092 - 288 WP_000965886.1 DUF1778 domain-containing protein Antitoxin
MCR19_RS20580 (4252258) 4252258..4252816 - 559 Protein_4011 cysteine hydrolase -
MCR19_RS20585 (4252905) 4252905..4254107 - 1203 WP_023201740.1 MFS transporter -
MCR19_RS20590 (4254192) 4254192..4254842 + 651 WP_023993641.1 GntR family transcriptional regulator -
MCR19_RS20595 (4254961) 4254961..4255389 - 429 Protein_4014 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(5-94)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17703.41 Da        Isoelectric Point: 9.8719

>T235566 WP_000533909.1 NZ_CP092040:c4251817-4251332 [Salmonella enterica subsp. enterica serovar Infantis]
VGRVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHGKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T235566 NZ_LR134305:c1818536-1818174 [Staphylococcus aureus]
ATGATTAGACGAGGAGATGTTTATTTAGCAGATTTATCACCAGTACAGGGATCTGAACAAGGGGGAGTCAGACCTGTAGT
CATAATTCAAAATGATACTGGTAATAAATATAGTCCTACAGTTATTGTTGCGGCAATAACTGGTAGGATTAATAAAGCGA
AAATACCGACACATGTAGAGATTGAAAAGAAAAAGTATAAATTGGATAAAGACTCAGTTATATTATTAGAACAAATTCGT
ACACTTGATAAAAAACGATTGAAAGAAAAACTGACGTACTTATCCGATGATAAAATGAAAGAAGTAGATAATGCACTAAT
GATTAGTTTAGGGCTGAATGCAGTAGCTCATCAGAAAAATTAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10950.60 Da        Isoelectric Point: 4.6811

>AT235566 WP_000965886.1 NZ_CP092040:c4252092-4251805 [Salmonella enterica subsp. enterica serovar Infantis]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDV

Download         Length: 288 bp

>AT235566 NZ_LR134305:c1818703-1818533 [Staphylococcus aureus]
ATGTTATCTTTTAGTCAAAATAGAAGTCATAGCTTAGAACAATCTTTAAAAGAAGGATATTCACAAATGGCTGATTTAAA
TCTCTCCCTAGCGAACGAAGCTTTTCCGATAGAGTGTGAAGCATGCGATTGCAACGAAACATATTTATCTTCTAATTCAA
CGAATGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 7F36
PDB 7AK8
PDB 5FVJ

Antitoxin

Source ID Structure
PDB 7AK8
AlphaFold DB A0A3V2JDX2

References