Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 3615322..3615982 Replicon chromosome
Accession NZ_CP092040
Organism Salmonella enterica subsp. enterica serovar Infantis strain S19

Toxin (Protein)


Gene name cptA Uniprot ID A0A5I5GR00
Locus tag MCR19_RS17485 Protein ID WP_000244761.1
Coordinates 3615322..3615735 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MCR19_RS17490 Protein ID WP_000351186.1
Coordinates 3615716..3615982 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCR19_RS17465 (3611263) 3611263..3612996 - 1734 WP_000813387.1 single-stranded-DNA-specific exonuclease RecJ -
MCR19_RS17470 (3613002) 3613002..3613715 - 714 WP_000745614.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MCR19_RS17475 (3613739) 3613739..3614635 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MCR19_RS17480 (3614748) 3614748..3615269 + 522 WP_001055885.1 flavodoxin FldB -
MCR19_RS17485 (3615322) 3615322..3615735 - 414 WP_000244761.1 protein YgfX Toxin
MCR19_RS17490 (3615716) 3615716..3615982 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MCR19_RS17495 (3616232) 3616232..3617212 + 981 WP_023260866.1 tRNA-modifying protein YgfZ -
MCR19_RS17500 (3617328) 3617328..3617987 - 660 WP_000250289.1 hemolysin III family protein -
MCR19_RS17505 (3618151) 3618151..3618462 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MCR19_RS17510 (3618620) 3618620..3620053 + 1434 WP_001230139.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16199.15 Da        Isoelectric Point: 10.7537

>T235564 WP_000244761.1 NZ_CP092040:c3615735-3615322 [Salmonella enterica subsp. enterica serovar Infantis]
VVLWQSDLRVSWRAQWISLLIHGLVSAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T235564 NZ_LR134305:1541756-1541851 [Staphylococcus aureus]
GTGATGCTTATTTTCGTTCACATCATAGCACCAGTCATCAGTGGCTGTGCCATTGCGTTTTTTTCTTATTGGCTAAGTAG
ACGCAATACAAAATAG

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT235564 WP_000351186.1 NZ_CP092040:c3615982-3615716 [Salmonella enterica subsp. enterica serovar Infantis]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235564 NZ_LR134305:c1541936-1541879 [Staphylococcus aureus]
AACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5I5GR00

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References