Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 3447986..3448800 Replicon chromosome
Accession NZ_CP092040
Organism Salmonella enterica subsp. enterica serovar Infantis strain S19

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A5T8FHB0
Locus tag MCR19_RS16710 Protein ID WP_023994249.1
Coordinates 3448273..3448800 (+) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag MCR19_RS16705 Protein ID WP_000855694.1
Coordinates 3447986..3448276 (+) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCR19_RS16675 (3443936) 3443936..3444586 - 651 WP_001728903.1 type III secretion system transcriptional activator InvF -
MCR19_RS16680 (3445042) 3445042..3445485 + 444 WP_023993678.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MCR19_RS16685 (3445917) 3445917..3446366 + 450 WP_000381612.1 membrane protein -
MCR19_RS16690 (3446351) 3446351..3446698 + 348 WP_001669174.1 DUF1493 family protein -
MCR19_RS16695 (3446971) 3446971..3447297 - 327 WP_000393300.1 hypothetical protein -
MCR19_RS16700 (3447538) 3447538..3447716 + 179 Protein_3255 IS3 family transposase -
MCR19_RS16705 (3447986) 3447986..3448276 + 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
MCR19_RS16710 (3448273) 3448273..3448800 + 528 WP_023994249.1 GNAT family N-acetyltransferase Toxin
MCR19_RS16715 (3448873) 3448873..3449090 - 218 Protein_3258 IS5/IS1182 family transposase -
MCR19_RS16720 (3449425) 3449425..3450081 + 657 WP_000420451.1 protein-serine/threonine phosphatase -
MCR19_RS16725 (3450252) 3450252..3450773 - 522 WP_023994250.1 hypothetical protein -
MCR19_RS16730 (3450932) 3450932..3453499 + 2568 WP_001005807.1 DNA mismatch repair protein MutS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- flank IS/Tn - - 3448873..3449013 140


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19025.89 Da        Isoelectric Point: 9.6423

>T235563 WP_023994249.1 NZ_CP092040:3448273-3448800 [Salmonella enterica subsp. enterica serovar Infantis]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHALQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRYDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNNQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T235563 NZ_LR134305:c562622-562434 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAATCCTATTTAAGTTTCACTGTCATTCTCTATATTTTCGGATTCGCTATTTTAA
TATACACATTTATATTTGGTGTACTATAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT235563 WP_000855694.1 NZ_CP092040:3447986-3448276 [Salmonella enterica subsp. enterica serovar Infantis]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT235563 NZ_LR134305:c562911-562651 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATTGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T8FHB0

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References