Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2102595..2103117 Replicon chromosome
Accession NZ_CP092040
Organism Salmonella enterica subsp. enterica serovar Infantis strain S19

Toxin (Protein)


Gene name stbE Uniprot ID B5F5Y5
Locus tag MCR19_RS10095 Protein ID WP_000221343.1
Coordinates 2102595..2102879 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID A0A5X3FYG4
Locus tag MCR19_RS10100 Protein ID WP_000885426.1
Coordinates 2102869..2103117 (-) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MCR19_RS10075 (2098674) 2098674..2100182 - 1509 WP_023993260.1 FAD-dependent oxidoreductase -
MCR19_RS10080 (2100227) 2100227..2100715 + 489 WP_001293634.1 MarR family winged helix-turn-helix transcriptional regulator -
MCR19_RS10085 (2100908) 2100908..2101987 + 1080 WP_023993261.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MCR19_RS10090 (2102035) 2102035..2102424 - 390 WP_023993262.1 RidA family protein -
MCR19_RS10095 (2102595) 2102595..2102879 - 285 WP_000221343.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MCR19_RS10100 (2102869) 2102869..2103117 - 249 WP_000885426.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MCR19_RS10105 (2103269) 2103269..2103484 + 216 WP_023993263.1 phage protein -
MCR19_RS10110 (2103474) 2103474..2103806 + 333 WP_000253154.1 DUF1493 family protein -
MCR19_RS10115 (2104086) 2104086..2104280 + 195 Protein_1969 hypothetical protein -
MCR19_RS10120 (2104279) 2104279..2104725 - 447 Protein_1970 helix-turn-helix domain-containing protein -
MCR19_RS10125 (2105631) 2105631..2106539 + 909 WP_023994284.1 LysR family transcriptional regulator -
MCR19_RS10130 (2106713) 2106713..2107693 + 981 WP_023993266.1 nitronate monooxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2100908..2109422 8514


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11075.85 Da        Isoelectric Point: 10.6500

>T235554 WP_000221343.1 NZ_CP092040:c2102879-2102595 [Salmonella enterica subsp. enterica serovar Infantis]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKMTRHRS

Download         Length: 285 bp

>T235554 NZ_LR134304:793318-793494 [Staphylococcus schweitzeri]
TTGGATAGATGGTGGCTATCTGAGTATAAGGAGGTGGTGCCTATGGTGGCATTACTGAAATCTTTAGAAAGGAGACGCCT
AATGATTACAATTAGTACCATGTTGCAGTTTGGTTTATTCCTTATTGCATTGATAGGTCTAGTAATCAAGCTTATTGAAT
TAAGCAATAAAAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9104.35 Da        Isoelectric Point: 3.9947

>AT235554 WP_000885426.1 NZ_CP092040:c2103117-2102869 [Salmonella enterica subsp. enterica serovar Infantis]
MAFQILTTTAASITELKRDPMGTFNAGEGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT235554 NZ_LR134304:c793656-793482 [Staphylococcus schweitzeri]
ATTTGATATTTATATTATGGTGTGTTAATTTATATATAGAAAAAGGGCAACATGCGCAAACACGTTACCCTAATGAACCC
GTTAAAAAGACGGTGGCTATTTTAGATTAAAGATTAAATTAATAACCATTTAACCATCGAAACCAGCCAAAGTTAGCGAT
GGTTATTTTTTATTG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5JSW4

Antitoxin

Source ID Structure
AlphaFold DB A0A5X3FYG4

References