Detailed information of TA system TA235553

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): Hha-TomB/-
• Location: 1109772..1110392
• Replicon: chromosome
• Accession: NZ_CP092040
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain S19

Toxin (Protein)

• Gene name: Hha
• Uniprot ID: V1H8E6
• Locus tag: MCR19_RS05215
• Protein ID: WP_001280991.1
• Coordinates: 1109772..1109990 (-)
• Length: 73 a.a.

Antitoxin (Protein)

• Gene name: TomB
• Uniprot ID: V1H4V6
• Locus tag: MCR19_RS05220
• Protein ID: WP_000344807.1
• Coordinates: 1110018..1110392 (-)
• Length: 125 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MCR19_RS05175 (1104995)	1104995..1105564	+	570	WP_000779802.1	YbaY family lipoprotein	-
MCR19_RS05180 (1105597)	1105597..1105986	-	390	WP_000961285.1	MGMT family protein	-
MCR19_RS05190 (1106217)	1106217..1107767	-	1551	WP_000213140.1	EAL domain-containing protein	-
MCR19_RS05195 (1107992)	1107992..1108252	+	261	WP_000801415.1	type B 50S ribosomal protein L31	-
MCR19_RS05200 (1108258)	1108258..1108398	+	141	WP_001197749.1	type B 50S ribosomal protein L36	-
MCR19_RS05205 (1108454)	1108454..1108924	-	471	WP_000136183.1	YlaC family protein	-
MCR19_RS05210 (1109042)	1109042..1109593	-	552	WP_001278793.1	maltose O-acetyltransferase	-
MCR19_RS05215 (1109772)	1109772..1109990	-	219	WP_001280991.1	HHA domain-containing protein	Toxin
MCR19_RS05220 (1110018)	1110018..1110392	-	375	WP_000344807.1	Hha toxicity modulator TomB	Antitoxin
MCR19_RS05225 (1110888)	1110888..1114037	-	3150	WP_001132508.1	efflux RND transporter permease AcrB	-
MCR19_RS05230 (1114060)	1114060..1115253	-	1194	WP_001039202.1	multidrug efflux RND transporter periplasmic adaptor subunit AcrA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Haemolysin expression modulating, HHA (13-69)

Antitoxin

• Biofilm formation regulator YbaJ (1-116)

Sequences

Toxin

Protein

• Length: 73 a.a.
• Molecular weight: 8613.97 Da
• Isoelectric Point: 8.9008

>T235553 WP_001280991.1 NZ_CP092040:c1109990-1109772 [Salmonella enterica subsp. enterica serovar Infantis]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Nucleotide

• Length: 219 bp

>T235553 NZ_LR134303:c3817712-3817311 [Shewanella putrefaciens]
TTGAATGACATTATTATCAATAAAATAGCCACCATCAAACGCTGTATAAAGCGCATCCAACAAGTCTATGGTGATGGAAG
CCAGTTCAAACAAGACTTCACCTTGCAAGATAGCGTTATCCTCAATTTACAACGCTGCTGCGAAGCCTGTATCGACATAG
CCAATCATATTAACCGCCAACAACAACTAGGCATCCCCCAAAGTAGCCGTGATAGCTTTACATTACTCGCACAAAATAAC
CTTATTACTCAGCCACTCGCAGATAACTTAAAGAAAATGGTCGGCCTGCGAAACATCGCAGTACATGACTACCAAGAACT
CAACCTTGATATCGTTGTCCATGTTGTACAGCATCATCTTGAGGATTTTGAGCAATTTATTGATGTGATAAAAGCAGAGT
GA

Antitoxin

Protein

• Length: 125 a.a.
• Molecular weight: 14453.27 Da
• Isoelectric Point: 5.1444

>AT235553 WP_000344807.1 NZ_CP092040:c1110392-1110018 [Salmonella enterica subsp. enterica serovar Infantis]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Nucleotide

• Length: 375 bp

>AT235553 NZ_LR134303:c3818127-3817705 [Shewanella putrefaciens]
ATGCAACAACTAAATGAAAAGAAAATCATAAAGTTACTGCGAGACAACATCCCAAAGTTGCAATTAATCTACCTGTTTGG
CTCTTATTCGCAGGGAACACAACACCGCAACAGCGATATCGATATCGCGGTACTCGCCGCTGACACTTTAGACAATATTG
CACGCTGGGAACTTGCCCAAAAACTCGCTTCGGCGTTGGACTCAGATGTTGATCTGGTTGATTTACGCTCAGCATCCACA
GTGTTATGCCAACAGGTAGTCACTCAAGGGAAGCAACTTTGGGGAACACAACAAGATGATGAACTTTTTGCCGTAAAGAC
CATCTCAATGTACCAACATCTACAAGCCGAAAGACAGGCAATTATTGATGATGTAATGGCCAACACCGCAGCCAAAGATC
ATAGGGGGAGTCACTTTGAATGA

Structures

Toxin

• PDB: 4ICG

Antitoxin

• AlphaFold DB: A0A5I5FGI0