Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 5028803..5030391 Replicon chromosome
Accession NZ_CP092039
Organism Pectobacterium brasiliense strain 130

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag MBA20_RS22195 Protein ID WP_119870763.1
Coordinates 5029072..5030391 (+) Length 440 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag MBA20_RS22190 Protein ID WP_103943261.1
Coordinates 5028803..5029072 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA20_RS22160 (MBA20_22160) 5023841..5024500 + 660 WP_014917137.1 DUF799 domain-containing protein -
MBA20_RS22165 (MBA20_22165) 5024623..5026125 - 1503 WP_119870760.1 MFS transporter -
MBA20_RS22170 (MBA20_22170) 5026229..5026780 + 552 WP_119870761.1 TetR/AcrR family transcriptional regulator -
MBA20_RS22175 (MBA20_22175) 5026811..5027221 - 411 WP_094431545.1 helix-turn-helix domain-containing protein -
MBA20_RS22180 (MBA20_22180) 5027364..5028215 + 852 WP_119870762.1 SDR family oxidoreductase -
MBA20_RS22185 (MBA20_22185) 5028344..5028610 + 267 Protein_4334 alpha/beta hydrolase -
MBA20_RS22190 (MBA20_22190) 5028803..5029072 + 270 WP_103943261.1 helix-turn-helix domain-containing protein Antitoxin
MBA20_RS22195 (MBA20_22195) 5029072..5030391 + 1320 WP_119870763.1 type II toxin-antitoxin system HipA family toxin Toxin
MBA20_RS22200 (MBA20_22200) 5030424..5031788 - 1365 WP_119870764.1 tRNA uridine-5-carboxymethylaminomethyl(34) synthesis GTPase MnmE -
MBA20_RS22205 (MBA20_22205) 5031918..5033552 - 1635 WP_010281240.1 membrane protein insertase YidC -
MBA20_RS22210 (MBA20_22210) 5033555..5033812 - 258 WP_010281237.1 membrane protein insertion efficiency factor YidD -
MBA20_RS22215 (MBA20_22215) 5033776..5034135 - 360 WP_010281235.1 ribonuclease P protein component -
MBA20_RS22220 (MBA20_22220) 5034154..5034294 - 141 WP_005976668.1 50S ribosomal protein L34 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(4-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-66)


Sequences

Toxin        


Download         Length: 440 a.a.        Molecular weight: 49397.67 Da        Isoelectric Point: 6.6897

>T235548 WP_119870763.1 NZ_CP092039:5029072-5030391 [Pectobacterium brasiliense]
MAALDVYMNGYRVGILTKTGSGAHHFSYDTNWLGLLGSRPISLSMPLRHQPYQGDEVYNFFDNLLPDNPDIRRRIVARHH
TDSTQPFDLLAKVGQDSVGALQLVPQGTPVHDIKKIEYKTLSEQQLENILTGYLSDAPLGMIDTEDDFRISIAGAQEKTA
LLYLDDRWCLPLNVTPTTHIIKLPIGKIESHSYSIDMSDSVENEYLCLLIAKAFGLPVPHCFMINAGKIKALAVERFDRK
YASDVSWIMRLPQEDFCQVLNVPSALKYENHGGPGISAIMSFLLGSVYPERDRYRFMQTQVLFWLLAATDGHAKNFSLFI
ESEGRYRLTPFYDILSMYPAMGGRGIDRREAKLAMGLTGSRGKKYAIEQIFPRHFFQTAKVVGFARESMENILAEFAQTV
DTVMTTVGSQLPVDFPTHISEAILAGLQARSRRLMSGWE

Download         Length: 1320 bp

>T235548 NZ_LR134303:c2447536-2447237 [Shewanella putrefaciens]
ATGAATAATAAACGCTATAAACTGAGTAGGTTAGCTCAGGCTCACCTACTAAAGATTAAAGACTACACCCTTCAACACTT
TTCTGAGTCGCAGTGGCACAAATACAAACAAAGCCTAATATCCGGCTTGCAAATGTTAGCCAATCACCCCGGATTAGGCA
GAAGCTGCAACGATATTTACCCCAACGGTTTCTACTTTCCTATCGGTAAACACACAGCCTACTTCACCAAAGAAGACGAC
TTTATCCTTATCGTTGCCCTGTTAGGTCAACCACAACTACCCCAAAATCATCTGAAATAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10062.40 Da        Isoelectric Point: 9.7281

>AT235548 WP_103943261.1 NZ_CP092039:5028803-5029072 [Pectobacterium brasiliense]
MMKITNSKQLSSYLKDVRITQKLSQGKVASKVGIRQDTVSSFEQHPDSTKLETFFKILSALNLELTVTPRNVDTTNNEAS
VASSWKEEW

Download         Length: 270 bp

>AT235548 NZ_LR134303:c2447787-2447545 [Shewanella putrefaciens]
ATGCAAACATTAACCGCCAATGACGCCAAACGAAATTTCGGTGAGTTGCTGCTAAACGCTCAACGTGAACCCATCAAGAT
CAGCAAAAACAGTAAAGATGTGGTTGTGGTCATGTCTATCCACGATTACGAACAGCTTGAGGCGATGAAAGCCGACTATC
TGAAGCACTGTTTCAACGCAGCCAAAGAAGATTTAGCGAAGGGCAATGTGGTTGATGGTGAAGATTTTCTTAACGCCCTG
TAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References