Detailed information of TA system TA235547

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 4884239..4884774
• Replicon: chromosome
• Accession: NZ_CP092039
• Organism: Pectobacterium brasiliense strain 130

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C6DJA0
• Locus tag: MBA20_RS21540
• Protein ID: WP_015842269.1
• Coordinates: 4884487..4884774 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q6DB37
• Locus tag: MBA20_RS21535
• Protein ID: WP_010281712.1
• Coordinates: 4884239..4884490 (+)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MBA20_RS21505 (MBA20_21505)	4879677..4880003	+	327	WP_039510297.1	helix-turn-helix domain-containing protein	-
MBA20_RS21510 (MBA20_21510)	4879988..4880302	+	315	WP_039279922.1	HipA N-terminal domain-containing protein	-
MBA20_RS21515 (MBA20_21515)	4880299..4881339	+	1041	WP_119871557.1	HipA domain-containing protein	-
MBA20_RS21520 (MBA20_21520)	4881399..4882022	-	624	WP_119871556.1	LysE family translocator	-
MBA20_RS21525 (MBA20_21525)	4882290..4883045	+	756	WP_119871555.1	thiol:disulfide interchange protein DsbG	-
MBA20_RS21530 (MBA20_21530)	4883079..4883984	-	906	WP_119871554.1	siderophore-interacting protein	-
MBA20_RS21535 (MBA20_21535)	4884239..4884490	+	252	WP_010281712.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MBA20_RS21540 (MBA20_21540)	4884487..4884774	+	288	WP_015842269.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MBA20_RS21545 (MBA20_21545)	4884892..4886244	-	1353	WP_119871553.1	glutathione-disulfide reductase	-
MBA20_RS21550 (MBA20_21550)	4886373..4887215	-	843	WP_010281707.1	23S rRNA (adenine(2030)-N(6))-methyltransferase RlmJ	-
MBA20_RS21555 (MBA20_21555)	4887496..4887879	-	384	WP_014913665.1	TfoX/Sxy family protein	-
MBA20_RS21560 (MBA20_21560)	4888001..4888531	-	531	WP_014913664.1	alkyl sulfatase dimerization domain-containing protein	-
MBA20_RS21565 (MBA20_21565)	4888734..4889462	+	729	WP_039498362.1	DUF1266 domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11074.15 Da
• Isoelectric Point: 10.3527

>T235547 WP_015842269.1 NZ_CP092039:4884487-4884774 [Pectobacterium brasiliense]
MSYSVKFREDALKEWLKLDKTIQQQFAKKLKKCCENPHIPSAKLRGMKDCYKIKLRASGFRLVYEVIDDVLIIAVVAVGK
RERSGVYHLASERMR

Nucleotide

• Length: 288 bp

>T235547 NZ_LR134303:c1326266-1325994 [Shewanella putrefaciens]
ATGACCTATAAGTTAGAGTTTGATCCCCGCGCCCTAAAGGAATGGAAGAAGCTCGGAGATCCCATCAGGCAGCAGCTAAA
AAAGAAATTGGCGGAGATACTGGAGCATCCCCATATCGAAGCGAACAAGCTCAGGGATCTCCCTGACTGTTACAAAATCA
AGTTGCGAACATCGGGATATCGCTTGGTATACCAAGTTCAAGATGAACGCATTACCGTGTTTGTCGTGGCCGTAGGCAAA
GGTAGTGTTCAAATTTCTGTGTCATTTCTTTAA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9117.47 Da
• Isoelectric Point: 4.0637

>AT235547 WP_010281712.1 NZ_CP092039:4884239-4884490 [Pectobacterium brasiliense]
MPNIILSDTSASVSELKKNPMATVNAGDGLPVAILNRNQPAFYCIPADLYEKMLDALDDQELVKLIGERKNQPLVDVDLD
SFL

Nucleotide

• Length: 252 bp

>AT235547 NZ_LR134303:c1326498-1326256 [Shewanella putrefaciens]
ATGGGCACAATCAACATACGCATCGATGACGAACTCAAAGAGCGTTCTTTTGCTGCATTGGAAAAATTAGGTGTAAGCCC
TTCAGAAGCCTTACGCCAGACGCTTGAATATGTCGCGACAAGAGGCGCTTTGCCCTTTAAGCCGGTACTGCTCACAGCAG
ATGATGAAGCCTTGATTACCTTGGTAAAAGAGCGTTTAGCGAACCCTCGCAAGGGGATCGAGGTTTCGCTCGATGACCTA
TAA

Structures

Toxin

• AlphaFold DB: A0A3S0XQ75

Antitoxin

• AlphaFold DB: A0A0M2EZP0