Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3523091..3523716 Replicon chromosome
Accession NZ_CP092039
Organism Pectobacterium brasiliense strain 130

Toxin (Protein)


Gene name Hha Uniprot ID C6DB72
Locus tag MBA20_RS15375 Protein ID WP_005976087.1
Coordinates 3523513..3523716 (+) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID Q6D809
Locus tag MBA20_RS15370 Protein ID WP_010282247.1
Coordinates 3523091..3523459 (+) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA20_RS15355 (MBA20_15355) 3518724..3521852 + 3129 WP_039511040.1 efflux RND transporter permease subunit -
MBA20_RS15360 (MBA20_15360) 3522083..3522331 + 249 WP_039274617.1 type B 50S ribosomal protein L31 -
MBA20_RS15365 (MBA20_15365) 3522349..3522492 + 144 WP_005976091.1 type B 50S ribosomal protein L36 -
MBA20_RS15370 (MBA20_15370) 3523091..3523459 + 369 WP_010282247.1 Hha toxicity modulator TomB Antitoxin
MBA20_RS15375 (MBA20_15375) 3523513..3523716 + 204 WP_005976087.1 HHA domain-containing protein Toxin
MBA20_RS15385 (MBA20_15385) 3524582..3524920 + 339 WP_119872104.1 MGMT family protein -
MBA20_RS15390 (MBA20_15390) 3524922..3525503 - 582 WP_119872105.1 YbaY family lipoprotein -
MBA20_RS15395 (MBA20_15395) 3525716..3526579 + 864 WP_119872106.1 acyl-CoA thioesterase II -
MBA20_RS15400 (MBA20_15400) 3526719..3528005 - 1287 WP_185893748.1 ammonium transporter AmtB -
MBA20_RS15405 (MBA20_15405) 3528045..3528383 - 339 WP_002208627.1 P-II family nitrogen regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-118)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8145.52 Da        Isoelectric Point: 8.9008

>T235538 WP_005976087.1 NZ_CP092039:3523513-3523716 [Pectobacterium brasiliense]
MKKIDYLMRLRKCTTIDTLERVIEKNKYELSNDELEMFFSAADHRLAELTMNKLYDKVPTAVWRYVR

Download         Length: 204 bp

>T235538 NZ_LR134301:4191613-4191891 [Stenotrophomonas maltophilia]
ATGATTCGTTCATTCCGCTGCAAGCAGACCCGTGCCCTGTTTGAAGGAACCTGCGCTCGCGCCTGGCGCCCGATACGACG
CGCTGCCGAACGAAAACTCCAACTGCTCGACTCGGCGCAGACGTTGGCGTTCCTGCGCAGCCCGCCCGGAAACCGGCTCG
AAGCACTGTCAGGTGACCGGAAGGGGCAGTACAGCCTTCGAATCAACGATCAGTGGCGACTCTGCTTTACCTGGACCGAC
AACGGCGCCGATGCCGTGGAAATTGTTGACTACCACTGA

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14046.80 Da        Isoelectric Point: 4.4787

>AT235538 WP_010282247.1 NZ_CP092039:3523091-3523459 [Pectobacterium brasiliense]
MDEYTPKHYDIAQLRFLCENLCDESIATLGDSSHGWVNDPTSAINLQLNELIEHIATFILTFKIKYPNESELSEQVEKYL
DDTYVLFSNYGINDAELRRWQKSKAKLFGMFSGENICTPAKT

Download         Length: 369 bp

>AT235538 NZ_LR134301:4191901-4192200 [Stenotrophomonas maltophilia]
ATGAAGCATCCCCACAACGGCATGCGCGCCATTCATCCTGGTGAGATCCTGCGCGAAGAGTTCCTGCTGCCGCTTGCGTT
GAGCGTGAACGCGCTTGCAAGGGCCTTGGACGTCCCCGCAACGCGGCTGCACGCCATCGTGCATGGCGAACGCGGCATCT
CGGCGGACACGGCCGCGCGGCTGGCGCGGCATTTCGGTGGGGATGCCGCATCCTGGCTTGCGATGCAGGCGGCTTACGAT
CTCAAGACGTTACCAACGCGCAACGAGATCGAGCGACGAGTGCAGCCGCGGGCAGCGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1D7Z3F0

Antitoxin

Source ID Structure
AlphaFold DB A0A086EI31

References