Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | yjhX-yjhQ/YjhX-GNAT |
| Location | 4184132..4184946 | Replicon | chromosome |
| Accession | NZ_CP092037 | ||
| Organism | Escherichia coli strain MG1655-377GD | ||
Toxin (Protein)
| Gene name | yjhX | Uniprot ID | S1PA82 |
| Locus tag | MBA16_RS20625 | Protein ID | WP_001054376.1 |
| Coordinates | 4184689..4184946 (-) | Length | 86 a.a. |
Antitoxin (Protein)
| Gene name | yjhQ | Uniprot ID | U9Z4B8 |
| Locus tag | MBA16_RS20620 | Protein ID | WP_001309181.1 |
| Coordinates | 4184132..4184677 (-) | Length | 182 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MBA16_RS20580 (4179402) | 4179402..4180034 | - | 633 | WP_000600622.1 | ribulose-phosphate 3 epimerase family protein | - |
| MBA16_RS20585 (4180046) | 4180046..4180168 | - | 123 | Protein_4000 | SgcA family PTS sugar transporter subunit IIA | - |
| MBA16_RS20590 (4180171) | 4180171..4181136 | - | 966 | Protein_4001 | PTS sugar transporter subunit IIC SgcC | - |
| MBA16_RS20595 (4181148) | 4181148..4181426 | - | 279 | WP_000722973.1 | PTS sugar transporter subunit IIB SgcB | - |
| MBA16_RS20600 (4181423) | 4181423..4182544 | - | 1122 | WP_000010829.1 | M42 family metallopeptidase | - |
| MBA16_RS20605 (4182789) | 4182789..4182905 | - | 117 | Protein_4004 | VOC family protein | - |
| MBA16_RS20610 (4182943) | 4182943..4183161 | - | 219 | Protein_4005 | hypothetical protein | - |
| MBA16_RS20615 (4183330) | 4183330..4184076 | - | 747 | WP_000354251.1 | class I SAM-dependent methyltransferase | - |
| MBA16_RS20620 (4184132) | 4184132..4184677 | - | 546 | WP_001309181.1 | N-acetyltransferase | Antitoxin |
| MBA16_RS20625 (4184689) | 4184689..4184946 | - | 258 | WP_001054376.1 | YjhX family toxin | Toxin |
| MBA16_RS20630 (4185437) | 4185437..4185568 | - | 132 | WP_001309182.1 | hypothetical protein | - |
| MBA16_RS20635 (4185684) | 4185684..4186249 | + | 566 | Protein_4010 | AAA domain-containing protein | - |
| MBA16_RS20640 (4186268) | 4186268..4186789 | - | 522 | Protein_4011 | N-acetylneuraminate epimerase | - |
| MBA16_RS20645 (4186809) | 4186809..4187525 | - | 717 | WP_001295734.1 | N-acetylneuraminic acid outer membrane channel NanC | - |
| MBA16_RS20650 (4188981) | 4188981..4189583 | + | 603 | WP_000790583.1 | type 1 fimbria switch DNA invertase FimB | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 86 a.a. Molecular weight: 9734.29 Da Isoelectric Point: 11.0090
>T235529 WP_001054376.1 NZ_CP092037:c4184946-4184689 [Escherichia coli]
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
MNLSRQEQHTLHVLAKGRRIAHVRDSSGRVTSVECYSREGLLLTDCTLAVFKKLKTKKLIKSVNGQPYRINTTELNKVRA
QLDNR
Download Length: 258 bp
>T235529 NZ_LR134299:5156671-5157138 [Pseudomonas putida]
ATGAGTGATGCGAGCAGGAAGCCTCTGGTTATTCATGGATGGACTGTAATTGCCCACCCGCTGTTCCTGGCCAAACTGGA
CGCGCTAAGCGCTCAAGTCGAGGCTCAACGGGACAAAGACCCAACGGGTTATACGAAAAGAAATACCTTTAAAAGGCTGG
CCGCCATCCGGCGGTTGGCGTTCGATGTAATCCCTCAAGACCCGACCAAACCCGAATACCGGCAAGGGGCAACACTTGGC
GGTGACCACAAGCACTGGTTCAGAGCAAAGTTCTTCCAGCAGTACCGGTTGTTCTTCCGCTACCACACCCCCAGCAGGAT
CATCGTGCTGGCCTGGATCAATGACGAGTCGAGCAAGCGGGCCTATGAAAGTAGCGACGATGCTTACAAGGTCTTTCAAA
AGATGTTGCATAGCGGCAACCCACCGGACGATTGGGACCAGTTGCTGCAAGAGGCTGCCGCAGATTGA
ATGAGTGATGCGAGCAGGAAGCCTCTGGTTATTCATGGATGGACTGTAATTGCCCACCCGCTGTTCCTGGCCAAACTGGA
CGCGCTAAGCGCTCAAGTCGAGGCTCAACGGGACAAAGACCCAACGGGTTATACGAAAAGAAATACCTTTAAAAGGCTGG
CCGCCATCCGGCGGTTGGCGTTCGATGTAATCCCTCAAGACCCGACCAAACCCGAATACCGGCAAGGGGCAACACTTGGC
GGTGACCACAAGCACTGGTTCAGAGCAAAGTTCTTCCAGCAGTACCGGTTGTTCTTCCGCTACCACACCCCCAGCAGGAT
CATCGTGCTGGCCTGGATCAATGACGAGTCGAGCAAGCGGGCCTATGAAAGTAGCGACGATGCTTACAAGGTCTTTCAAA
AGATGTTGCATAGCGGCAACCCACCGGACGATTGGGACCAGTTGCTGCAAGAGGCTGCCGCAGATTGA
Antitoxin
Download Length: 182 a.a. Molecular weight: 19956.90 Da Isoelectric Point: 6.3277
>AT235529 WP_001309181.1 NZ_CP092037:c4184677-4184132 [Escherichia coli]
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
MTVHHFTFHITDKSDASDIREVETRAFGFSKEADLVASLLEDESARPALSLLARYEGKAVGHILFTRATFKGEMDSPLMH
ILAPLAVIPEYQGMGVGGRLIRTGIEHLRLMGCQTVFVLGHATYYPRHGFEPCAGDKGYPAPYPIPEEHKACWMMQSLTA
QPMTLTGHIRCADPDETGALT
Download Length: 546 bp
>AT235529 NZ_LR134299:5156348-5156674 [Pseudomonas putida]
ATGGCTGCCACCTTCGACGTCGAGTCCACGCTGACCGATCGCTATCAAACCACTGTTCCCGAAACGGTGCGGCGCGCCTT
GGGCTTGAAAAAACGTGACAAGATCCATTACTCGATTCGCCCCGACGGTGGGGTGATACTCACCCGCGCAGAGGCAACCG
AGGACGATCCGGTACTGGGCAAATTTCTGGATTTCCTGGCACACGATATCGCTACCAACCCTCAACGGCTGCAGGTTGTC
GATGCTGGCCTCATCGCGCGCCTCGACAAGCTTGTCGGCGACGCGGAGGTCGACCTGGATCAACCTCTGTCGGCGGACGA
TGAATGA
ATGGCTGCCACCTTCGACGTCGAGTCCACGCTGACCGATCGCTATCAAACCACTGTTCCCGAAACGGTGCGGCGCGCCTT
GGGCTTGAAAAAACGTGACAAGATCCATTACTCGATTCGCCCCGACGGTGGGGTGATACTCACCCGCGCAGAGGCAACCG
AGGACGATCCGGTACTGGGCAAATTTCTGGATTTCCTGGCACACGATATCGCTACCAACCCTCAACGGCTGCAGGTTGTC
GATGCTGGCCTCATCGCGCGCCTCGACAAGCTTGTCGGCGACGCGGAGGTCGACCTGGATCAACCTCTGTCGGCGGACGA
TGAATGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|