Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 1344068..1344706 Replicon chromosome
Accession NZ_CP092037
Organism Escherichia coli strain MG1655-377GD

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag MBA16_RS06705 Protein ID WP_000813794.1
Coordinates 1344068..1344244 (+) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag MBA16_RS06710 Protein ID WP_001270286.1
Coordinates 1344290..1344706 (+) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MBA16_RS06685 (1339687) 1339687..1340901 - 1215 WP_001326689.1 BenE family transporter YdcO -
MBA16_RS06690 (1340954) 1340954..1341490 + 537 WP_000429155.1 DNA-binding transcriptional regulator SutR -
MBA16_RS06695 (1341563) 1341563..1343524 + 1962 WP_001303492.1 23S rRNA 5-hydroxycytidine C2501 synthase -
MBA16_RS06700 (1343616) 1343616..1343846 - 231 WP_000494244.1 YncJ family protein -
MBA16_RS06705 (1344068) 1344068..1344244 + 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
MBA16_RS06710 (1344290) 1344290..1344706 + 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
MBA16_RS06715 (1344785) 1344785..1346191 + 1407 WP_000760626.1 PLP-dependent aminotransferase family protein -
MBA16_RS06720 (1346436) 1346436..1347581 + 1146 WP_000047424.1 ABC transporter substrate-binding protein -
MBA16_RS06725 (1347599) 1347599..1348612 + 1014 WP_000220396.1 ABC transporter ATP-binding protein -
MBA16_RS06730 (1348613) 1348613..1349554 + 942 WP_001251304.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T235509 WP_000813794.1 NZ_CP092037:1344068-1344244 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

>T235509 NZ_LR134296:1966143-1966246 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT235509 WP_001270286.1 NZ_CP092037:1344290-1344706 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp

>AT235509 NZ_LR134296:c1966284-1966013 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References