Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 10341..11259 Replicon plasmid p15516C-1
Accession NZ_CP092035
Organism Campylobacter jejuni subsp. jejuni strain 15516C

Toxin (Protein)


Gene name Fic Uniprot ID A0A5T1Y6U9
Locus tag MA850_RS09220 Protein ID WP_019109036.1
Coordinates 10341..11024 (-) Length 228 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID A0A3Z9GMV3
Locus tag MA850_RS09225 Protein ID WP_002907823.1
Coordinates 11017..11259 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA850_RS09190 (MA850_09190) 6809..7363 - 555 WP_079460393.1 GNAT family N-acetyltransferase -
MA850_RS09615 7485..7613 + 129 WP_257408334.1 hypothetical protein -
MA850_RS09195 (MA850_09195) 7710..7934 - 225 WP_052796192.1 hypothetical protein -
MA850_RS09200 (MA850_09200) 7937..8623 - 687 WP_002907859.1 AAA family ATPase -
MA850_RS09205 (MA850_09205) 8704..9099 - 396 WP_052796193.1 conjugal transfer protein TraM -
MA850_RS09210 (MA850_09210) 9132..9780 - 649 Protein_13 DNA/RNA non-specific endonuclease -
MA850_RS09215 (MA850_09215) 9869..10336 - 468 WP_002907837.1 signal peptidase I -
MA850_RS09220 (MA850_09220) 10341..11024 - 684 WP_019109036.1 Fic family protein Toxin
MA850_RS09225 (MA850_09225) 11017..11259 - 243 WP_002907823.1 hypothetical protein Antitoxin
MA850_RS09230 (MA850_09230) 11351..12070 - 720 WP_052796195.1 conjugal transfer protein TraL -
MA850_RS09235 (MA850_09235) 12087..13910 - 1824 WP_052796196.1 type IV secretory system conjugative DNA transfer family protein -
MA850_RS09240 (MA850_09240) 13907..16120 - 2214 WP_052796197.1 zincin-like metallopeptidase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..30658 30658


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(60-169)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 228 a.a.        Molecular weight: 26138.30 Da        Isoelectric Point: 10.1130

>T235500 WP_019109036.1 NZ_CP092035:c11024-10341 [Campylobacter jejuni subsp. jejuni]
MIDKVLKFLDDGIPKNDFDRQLLASNLVGATNLIELNKREREITLKKQLKLQLNPIKGNFDYQHLKDIHKALFEDVYTWA
GQDRMQMGLKEKFAKYAPNGAIINFVPGKELDKYSKIIFDELAKNNYLKNSKDLNHFAKNLAKFMGEINALHPFREGNGR
TQRIFLNELAKNAGYKLDLNLISKHKMIHACAEASQLKPGRLEALIKDNLKNFRQNLDLEQNKGISL

Download         Length: 684 bp

>T235500 NZ_LR134295:c4010014-4009727 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9276.49 Da        Isoelectric Point: 4.3697

>AT235500 WP_002907823.1 NZ_CP092035:c11259-11017 [Campylobacter jejuni subsp. jejuni]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEGIKSVICGHAIEDMFANEKDVIDMIKIAKDEANADEIIAEYKREWGVND

Download         Length: 243 bp

>AT235500 NZ_LR134295:c4009740-4009438 [Escherichia coli]
ATGAGCATGGTTAAACATAAACGAGGGACCTCCTCTACACTCGATGTGCAGCATGAGGCCGAACTGAAGGCGCTGGCGAA
TAAATCCGACGAAGATATTGATTACAGTGATATCCCACCTTCCAGCGATGAGCAATGGTCTAACGCCGAACGCGGTAAGT
TTTATCGGCCATTGAAAACTCAGGCTTCGGTGCGTATTGATGCTGATGTGATGGAATGGTTGAAGCGACCAGGTAAAGGC
TATCAAACTCGCCTGAACGCAATTTTACGTGAAGCGATGCTGCGCGATCAGAACAAAAAATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5T1Y6U9

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z9GMV3

References