Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) FicTA/Fic(toxin)
Location 4680..5581 Replicon plasmid p14240-1-1
Accession NZ_CP092027
Organism Campylobacter coli strain 14240-1

Toxin (Protein)


Gene name Fic Uniprot ID A0A3Z8TY88
Locus tag MA853_RS09075 Protein ID WP_002814355.1
Coordinates 4680..5342 (-) Length 221 a.a.

Antitoxin (Protein)


Gene name Fti Uniprot ID C5F2H5
Locus tag MA853_RS09080 Protein ID WP_002814351.1
Coordinates 5342..5581 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA853_RS09045 (MA853_09045) 1..384 + 384 WP_002823902.1 hypothetical protein -
MA853_RS09050 (MA853_09050) 347..2503 + 2157 WP_002838514.1 relaxase/mobilization nuclease domain-containing protein -
MA853_RS09055 (MA853_09055) 2744..2968 - 225 WP_002790621.1 hypothetical protein -
MA853_RS09060 (MA853_09060) 2971..3657 - 687 WP_215447250.1 AAA family ATPase -
MA853_RS09065 (MA853_09065) 3749..4144 - 396 WP_002779833.1 conjugal transfer protein TraM -
MA853_RS09070 (MA853_09070) 4208..4675 - 468 WP_002845425.1 signal peptidase I -
MA853_RS09075 (MA853_09075) 4680..5342 - 663 WP_002814355.1 Fic family protein Toxin
MA853_RS09080 (MA853_09080) 5342..5581 - 240 WP_002814351.1 hypothetical protein Antitoxin
MA853_RS09085 (MA853_09085) 5684..6403 - 720 WP_002844665.1 conjugal transfer protein TraL -
MA853_RS09090 (MA853_09090) 6414..8237 - 1824 WP_238522885.1 type IV secretory system conjugative DNA transfer family protein -
MA853_RS09095 (MA853_09095) 8234..10447 - 2214 WP_002795783.1 zincin-like metallopeptidase domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..25383 25383


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(53-162)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 221 a.a.        Molecular weight: 25478.46 Da        Isoelectric Point: 10.1005

>T235495 WP_002814355.1 NZ_CP092027:c5342-4680 [Campylobacter coli]
MWDSQENLSEFDKFLIKTNKIGAKSLDELFRKERMITNKKALELGKNPIKGNFDYQHLKDIHKALFEDVYTWAGQDRMQM
GLKEKFAKYAPNGAIINFVPGKELDKYSKIIFDELAKNNYLKNSKDLNHFAKNLAKFMGEINALHPFREGNGRTQRIFLN
ELAKNAGYKLDLNLISKHKMIHACVEASQLKPGRLEALIKDNLKNFRQNLDLEQNKGMSL

Download         Length: 663 bp

>T235495 NZ_LR134295:2677197-2677304 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 9089.40 Da        Isoelectric Point: 4.6535

>AT235495 WP_002814351.1 NZ_CP092027:c5581-5342 [Campylobacter coli]
MQKQYPEVHSLEESLAILKKYKDDLTKEQYEAIRSNIGNFAIEDMFLNEKDIIDNVKIIKGEATANECIVALKKEWGVS

Download         Length: 240 bp

>AT235495 NZ_LR134295:c2677150-2677084 [Escherichia coli]
TGTCTGGTTTCAAGATTAGCCCCCGTTTTGTTGTCAGGTTTTACCTCTCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z8TY88

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z9DV79

References