Detailed information of TA system TA235494

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-DnaT
• Location: 3217703..3218225
• Replicon: chromosome
• Accession: NZ_CP092014
• Organism: Edwardsiella ictaluri strain 13 TAL-140 K3

Toxin (Protein)

• Gene name: relE
• Uniprot ID: C5BBL4
• Locus tag: MAY91_RS15650
• Protein ID: WP_015871319.1
• Coordinates: 3217703..3217984 (-)
• Length: 94 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: C5BBL3
• Locus tag: MAY91_RS15655
• Protein ID: WP_015871318.1
• Coordinates: 3217974..3218225 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAY91_RS15635 (MAY91_15575)	3213090..3213866	+	777	WP_015871322.1	hypothetical protein	-
MAY91_RS15640 (MAY91_15580)	3213859..3215520	+	1662	WP_278068547.1	terminase	-
MAY91_RS15645 (MAY91_15585)	3215517..3217631	+	2115	WP_015871320.1	hypothetical protein	-
MAY91_RS15650 (MAY91_15590)	3217703..3217984	-	282	WP_015871319.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MAY91_RS15655 (MAY91_15595)	3217974..3218225	-	252	WP_015871318.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MAY91_RS15660 (MAY91_15600)	3218513..3219514	+	1002	WP_015871317.1	hypothetical protein	-
MAY91_RS15665 (MAY91_15605)	3219532..3220789	+	1258	Protein_3002	N4-gp56 family major capsid protein	-
MAY91_RS15670 (MAY91_15610)	3220947..3221342	+	396	WP_049640651.1	hypothetical protein	-
MAY91_RS15675 (MAY91_15615)	3221384..3221827	+	444	WP_015871314.1	hypothetical protein	-
MAY91_RS15680 (MAY91_15620)	3221893..3222408	+	516	WP_232347282.1	hypothetical protein	-
MAY91_RS15685 (MAY91_15625)	3222408..3223070	+	663	WP_015871312.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	3179775..3237664	57889

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 94 a.a.
• Molecular weight: 10783.62 Da
• Isoelectric Point: 10.6993

>T235494 WP_015871319.1 NZ_CP092014:c3217984-3217703 [Edwardsiella ictaluri]
MTYKLSFEKRALKEWKKLAPPIQSQLKKKLIERLENPHVPAARLSGRANRYKIKLRSSGYRLVYEVNDSEIILLVIAIGK
RADNEVYQAADSR

Nucleotide

• Length: 282 bp

>T235494 NZ_LR134295:c2516964-2516677 [Escherichia coli]
ATGGCGTATTTTCTGGATTTTGACGAGCGGGCACTAAAGGAATGGCGAAAGCTGGGCTCGACGGTACGTGAACAGTTGAA
AAAGAAGCTGGTTGAAGTACTTGAGTCACCCCGGATTGAAGCAAACAAGCTCCGTGGTATGCCTGATTGTTACAAGATTA
AGCTCCGGTCTTCAGGCTATCGCCTTGTATACCAGGTTATAGACGAGAAAGTTGTCGTTTTCGTGATTTCTGTTGGGAAA
AGAGAACGCTCGGAAGTATATAGCGAGGCGGTCAAACGCATTCTCTGA

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9155.24 Da
• Isoelectric Point: 3.7550

>AT235494 WP_015871318.1 NZ_CP092014:c3218225-3217974 [Edwardsiella ictaluri]
MAYQILTTTAASITDLKRNPMGTIAEGDGNAVAILNRNEPAFYCVPPELYAYYLELAEDAALNRIADERLEDAEFVSVNI
DDL

Nucleotide

• Length: 252 bp

>AT235494 NZ_LR134295:c2517203-2516964 [Escherichia coli]
ATGGGTAGCATTAACCTGCGTATTGACGATGAACTTAAAGCGCGTTCTTACGCCGCGCTTGAAAAAATGGGTGTAACTCC
TTCTGAAGCGCTTCGTCTCATGCTCGAGTATATCGCTGACAATGAACGCTTGCCGTTCAAACAGACACTCCTGAGTGATG
AAGATGCTGAACTTGTGGAGATAGTGAAAGAACGGCTTCGTAATCCTAAGCCAGTACGTGTGACGCTGGATGAACTCTGA

Structures

Toxin

• AlphaFold DB: C5BBL4

Antitoxin

• AlphaFold DB: C5BBL3