Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 2553091..2553683 Replicon chromosome
Accession NZ_CP092014
Organism Edwardsiella ictaluri strain 13 TAL-140 K3

Toxin (Protein)


Gene name Hha Uniprot ID D0ZEC2
Locus tag MAY91_RS12280 Protein ID WP_012847872.1
Coordinates 2553091..2553294 (-) Length 68 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID C5BCY7
Locus tag MAY91_RS12285 Protein ID WP_015870487.1
Coordinates 2553315..2553683 (-) Length 123 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAY91_RS12240 (MAY91_12195) 2548310..2548771 + 462 WP_049640186.1 Lrp/AsnC family transcriptional regulator -
MAY91_RS12245 (MAY91_12200) 2548800..2549015 - 216 WP_128574010.1 hypothetical protein -
MAY91_RS12250 (MAY91_12205) 2549070..2549408 + 339 WP_015870482.1 P-II family nitrogen regulator -
MAY91_RS12255 (MAY91_12210) 2549430..2550711 + 1282 Protein_2353 ammonium transporter AmtB -
MAY91_RS12260 (MAY91_12215) 2550745..2551611 - 867 WP_015870484.1 acyl-CoA thioesterase II -
MAY91_RS12265 (MAY91_12220) 2551657..2551986 - 330 WP_015870485.1 MGMT family protein -
MAY91_RS12275 (MAY91_12230) 2552964..2553071 + 108 Protein_2356 IS5/IS1182 family transposase -
MAY91_RS12280 (MAY91_12235) 2553091..2553294 - 204 WP_012847872.1 HHA domain-containing protein Toxin
MAY91_RS12285 (MAY91_12240) 2553315..2553683 - 369 WP_015870487.1 Hha toxicity modulator TomB Antitoxin
MAY91_RS12290 (MAY91_12245) 2554043..2557195 - 3153 WP_015870488.1 efflux RND transporter permease subunit -
MAY91_RS12295 (MAY91_12250) 2557239..2558423 - 1185 WP_049640188.1 efflux RND transporter periplasmic adaptor subunit -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(8-64)

Antitoxin

Biofilm formation regulator YbaJ

(1-115)


Sequences

Toxin        


Download         Length: 68 a.a.        Molecular weight: 8103.37 Da        Isoelectric Point: 5.0914

>T235491 WP_012847872.1 NZ_CP092014:c2553294-2553091 [Edwardsiella ictaluri]
MTKIDYLMKLRKCTTLDTLERVIEKNKYELSDDELEIFYSAADHRLAELTMNKLYDKIPAEVWQYVR

Download         Length: 204 bp

>T235491 NZ_LR134295:2009376-2009479 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 123 a.a.        Molecular weight: 14287.03 Da        Isoelectric Point: 5.4786

>AT235491 WP_015870487.1 NZ_CP092014:c2553683-2553315 [Edwardsiella ictaluri]
MDENTSYQHDISELKYLCDYLYHQGIDVLGESNHGWVSDPTAEVNLQLNELIEHIASIAQSFKIKYPRHSDLAEMLDYYL
DETYALFGTYSISETALRQWLRTKRRMAYCLAHEKRNAALHV

Download         Length: 369 bp

>AT235491 NZ_LR134295:c2009517-2009246 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGCGGTAGTCATCAGCTTAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A034SMG4

Antitoxin

Source ID Structure
AlphaFold DB C5BCY7

References