Detailed information of TA system TA235490

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tad-ata/COG5606-COG4679
• Location: 2295667..2296330
• Replicon: chromosome
• Accession: NZ_CP092014
• Organism: Edwardsiella ictaluri strain 13 TAL-140 K3

Toxin (Protein)

• Gene name: tad
• Uniprot ID: C5B7U4
• Locus tag: MAY91_RS10970
• Protein ID: WP_015870280.1
• Coordinates: 2295986..2296330 (-)
• Length: 115 a.a.

Antitoxin (Protein)

• Gene name: ata
• Uniprot ID: -
• Locus tag: MAY91_RS10965
• Protein ID: WP_015870279.1
• Coordinates: 2295667..2295984 (-)
• Length: 106 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MAY91_RS10920 (MAY91_10895)	2290996..2291545	+	550	Protein_2087	YaeQ family protein	-
MAY91_RS10925 (MAY91_10900)	2291547..2291963	+	417	WP_015870272.1	alternative ribosome rescue aminoacyl-tRNA hydrolase ArfB	-
MAY91_RS10930 (MAY91_10905)	2292060..2292737	+	678	WP_015870273.1	envelope stress response activation lipoprotein NlpE	-
MAY91_RS10935 (MAY91_10910)	2292759..2293019	-	261	WP_015870274.1	YfhL family 4Fe-4S dicluster ferredoxin	-
MAY91_RS10940 (MAY91_10915)	2293625..2293903	+	279	WP_133175613.1	hypothetical protein	-
MAY91_RS10950 (MAY91_10925)	2294848..2295027	+	180	WP_071525714.1	hypothetical protein	-
MAY91_RS10955	2295132..2295260	+	129	WP_015870277.1	hypothetical protein	-
MAY91_RS10960 (MAY91_10930)	2295257..2295634	+	378	WP_015870278.1	type II toxin-antitoxin system death-on-curing family toxin	-
MAY91_RS10965 (MAY91_10935)	2295667..2295984	-	318	WP_015870279.1	helix-turn-helix transcriptional regulator	Antitoxin
MAY91_RS10970 (MAY91_10940)	2295986..2296330	-	345	WP_015870280.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MAY91_RS10975 (MAY91_10945)	2296502..2296720	-	219	WP_232347353.1	head completion/stabilization protein	-
MAY91_RS10980 (MAY91_10950)	2296749..2297537	+	789	WP_278068232.1	phage portal protein	-
MAY91_RS10985 (MAY91_10955)	2298561..2299415	-	855	Protein_2100	MurR/RpiR family transcriptional regulator	-
MAY91_RS10990 (MAY91_10960)	2299571..2300215	+	645	WP_226092411.1	phosphatidylglycerophosphatase C	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Prophage	-	-	2295257..2307018	11761

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin HigB-like (12-105)

Antitoxin

• Cro/C1-type helix-turn-helix domain (34-86)

Sequences

Toxin

Protein

• Length: 115 a.a.
• Molecular weight: 12544.34 Da
• Isoelectric Point: 9.8474

>T235490 WP_015870280.1 NZ_CP092014:c2296330-2295986 [Edwardsiella ictaluri]
MKSLYWVGSTKKDLQSLPEEVQDIFGYALHLAQVGGKHSQTKPLKGFSGAGVLEVVEDFLGDTYRAVYTVKFGDAVYVSH
VFQKKSSSGIATPKLNMDKIRERLKAAENHARGA

Nucleotide

• Length: 345 bp

>T235490 NZ_LR134295:988552-988887 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin

Protein

• Length: 106 a.a.
• Molecular weight: 11480.41 Da
• Isoelectric Point: 10.2058

>AT235490 WP_015870279.1 NZ_CP092014:c2295984-2295667 [Edwardsiella ictaluri]
MSHDIEVSSGNVYVDIGRDDAEEMLLKAQLATTIGNIIKSRSLTQEQAAKLLGMTQPKLSNMLRGQFRGISEAKMLECLT
RLGRDVQIVVGKPRRTPGSVKVVLA

Nucleotide

• Length: 318 bp

>AT235490 NZ_LR134295:988304-988552 [Escherichia coli]
ATGATCCACAGTAGCGTAAAGCGTTGGGGAAATTCACCGGCGGTGCGGATCCCGGCTACGTTAATGCAGGCGCTCAATCT
GAATATTGATGATGAAGTGAAGATTGACCTGGTGGATGGCAAATTAATTATTGAGCCAGTGCGTAAAGAGCCCGTATTTA
CGCTTGCTGAACTGGTCAACGACATCACGCCGGAAAACCTCCACGAGAATATCGACTGGGGAGAGCCGAAAGATAAGGAA
GTCTGGTAA

Structures

Toxin

• AlphaFold DB: C5B7U4