Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 827966..828629 Replicon chromosome
Accession NZ_CP092014
Organism Edwardsiella ictaluri strain 13 TAL-140 K3

Toxin (Protein)


Gene name cptA Uniprot ID C5BAS3
Locus tag MAY91_RS04010 Protein ID WP_015872556.1
Coordinates 827966..828382 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID -
Locus tag MAY91_RS04015 Protein ID WP_049640283.1
Coordinates 828363..828629 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MAY91_RS03990 (MAY91_03980) 823889..825623 - 1735 Protein_768 single-stranded-DNA-specific exonuclease RecJ -
MAY91_RS03995 (MAY91_03985) 825628..826344 - 717 WP_015872553.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MAY91_RS04000 (MAY91_03990) 826372..827271 - 900 WP_015872554.1 site-specific tyrosine recombinase XerD -
MAY91_RS04005 (MAY91_03995) 827429..827941 + 513 WP_015872555.1 flavodoxin FldB -
MAY91_RS04010 (MAY91_04000) 827966..828382 - 417 WP_015872556.1 protein YgfX Toxin
MAY91_RS04015 (MAY91_04005) 828363..828629 - 267 WP_049640283.1 FAD assembly factor SdhE Antitoxin
MAY91_RS04020 (MAY91_04010) 828977..829972 + 996 WP_049640284.1 tRNA-modifying protein YgfZ -
MAY91_RS04025 (MAY91_04015) 830013..830837 - 825 WP_015872559.1 shikimate 5-dehydrogenase -
MAY91_RS04030 (MAY91_04020) 830999..831871 - 873 WP_015872560.1 nucleoside-specific channel-forming protein Tsx -
MAY91_RS04035 (MAY91_04025) 832480..833129 + 650 Protein_777 hemolysin III family protein -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 139 a.a.        Molecular weight: 16145.89 Da        Isoelectric Point: 11.3233

>T235488 WP_015872556.1 NZ_CP092014:c828382-827966 [Edwardsiella ictaluri]
VALWRCNVHASWRTQVMFLLGHGALVLAILLAPWPENYSVFWLILLVAVIFECIRSQRLIARNSGELQRLAPQVWHWQLR
EWRLARRPWVSDLGALLILQSTHGTPCRRRLWLAADSMSREEWGQLRRALLDTGDDRV

Download         Length: 417 bp

>T235488 NZ_LR134295:713600-713896 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10306.88 Da        Isoelectric Point: 6.4543

>AT235488 WP_049640283.1 NZ_CP092014:c828629-828363 [Edwardsiella ictaluri]
MDINNKARVHWACRRGMRELDIAIMPFFEHEYDALNDADKQTFVRLLSCDDPELFKWLMNQGKPGDTDLARMITLIQTRN
KERGPLAL

Download         Length: 267 bp

>AT235488 NZ_LR134295:713898-714293 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB C5BAS3


Antitoxin

Source ID Structure

References