Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4325881..4326662 Replicon chromosome
Accession NZ_CP092012
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N12-0259

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag MA624_RS21075 Protein ID WP_000625911.1
Coordinates 4325881..4326372 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag MA624_RS21080 Protein ID WP_001271379.1
Coordinates 4326369..4326662 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA624_RS21050 (4321017) 4321017..4323455 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
MA624_RS21055 (4323465) 4323465..4324004 - 540 WP_000721295.1 type 1 fimbrial protein -
MA624_RS21060 (4324039) 4324039..4324329 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
MA624_RS21065 (4324916) 4324916..4325143 + 228 WP_001112992.1 hypothetical protein -
MA624_RS21070 (4325418) 4325418..4325666 - 249 Protein_4122 IS481 family transposase -
MA624_RS21075 (4325881) 4325881..4326372 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
MA624_RS21080 (4326369) 4326369..4326662 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
MA624_RS21085 (4326980) 4326980..4327201 + 222 WP_052939504.1 hypothetical protein -
MA624_RS21090 (4327467) 4327467..4328342 + 876 WP_023205266.1 AraC family transcriptional regulator -
MA624_RS21095 (4328339) 4328339..4328626 + 288 WP_072103482.1 transcriptional regulator RtsB -
MA624_RS21100 (4328619) 4328619..4328801 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
MA624_RS21105 (4328821) 4328821..4328920 + 100 Protein_4129 hypothetical protein -
MA624_RS21110 (4328968) 4328968..4329162 + 195 WP_223163373.1 hypothetical protein -
MA624_RS21115 (4329457) 4329457..4330362 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4312859..4328801 15942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T235485 WP_000625911.1 NZ_CP092012:c4326372-4325881 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T235485 NZ_LR134295:180073-180180 [Escherichia coli]
ATGACGTTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT235485 WP_001271379.1 NZ_CP092012:c4326662-4326369 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT235485 NZ_LR134295:c180025-179959 [Escherichia coli]
GGTCTAGAGTCAAGATTAGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References