Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4187695..4188338 Replicon chromosome
Accession NZ_CP092012
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N12-0259

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag MA624_RS20345 Protein ID WP_000048134.1
Coordinates 4187922..4188338 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag MA624_RS20340 Protein ID WP_001261294.1
Coordinates 4187695..4187925 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA624_RS20330 (4184708) 4184708..4186846 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MA624_RS20335 (4187063) 4187063..4187527 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MA624_RS20340 (4187695) 4187695..4187925 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MA624_RS20345 (4187922) 4187922..4188338 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
MA624_RS20350 (4188399) 4188399..4190312 - 1914 WP_001212148.1 BglG family transcription antiterminator -
MA624_RS20355 (4190329) 4190329..4191069 - 741 WP_000779255.1 KDGP aldolase family protein -
MA624_RS20360 (4191066) 4191066..4192184 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MA624_RS20365 (4192168) 4192168..4193301 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T235484 WP_000048134.1 NZ_CP092012:4187922-4188338 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T235484 NZ_LR134294:c1154134-1153961 [Streptococcus pneumoniae]
ATGACACAAAAAGAGATGGTTAAACTCCTTACGGCCCATGGTTGGATAAAGACTAGAGGCGGTAAAGGCTCTCATATTAA
AATCGAGAAGCAAGGGGAAAGACCTATCACAATCCTTCATGGTGAGCTGAATAAGTACACTGAAAGAGGGATAGGAAAGC
AAGTTGGGTTGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT235484 WP_001261294.1 NZ_CP092012:4187695-4187925 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT235484 NZ_LR134294:c1153924-1153472 [Streptococcus pneumoniae]
ATGTTAGTTACGTATCCAGCTTTATTTTATTATGACGACACAGACGGAACAGAAGCGACTTATTTTGTCCATTTCCCAGA
TTTTGAATACTCAGCTACACAAGGAGAGGGGATTTCTGAGGCTTTGGCTATGGGGTCGGAGTGGCTAGGGATAACTGTTG
CAGATTTGATAGAGAGTGATGGAGAGTTACCTCAGCCATCAGATATCAATAGCTTGTCTTTAATTGATAATGATCCTTTT
AAAGATGATGAAGATTTCGTGTCAACCTATGACCTTGATAAATCTTTTATTTCTATGGTATCTGTTGATGTATCAGAATA
CCTAGGAAGTCAGGAACCCATTAAAAAGACTTTGACCATACCAAAATGGGCAGATAAGTTGGGACGAGAAATGGGACTTA
ACTTTTCTCAGACTTTGACAGACGCTATTGCAGATAAGAAAGTTCAAGCCTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References