Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3454552..3455172 Replicon chromosome
Accession NZ_CP092012
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N12-0259

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MA624_RS16985 Protein ID WP_001280991.1
Coordinates 3454954..3455172 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MA624_RS16980 Protein ID WP_000344807.1
Coordinates 3454552..3454926 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA624_RS16970 (3449691) 3449691..3450884 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MA624_RS16975 (3450907) 3450907..3454056 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MA624_RS16980 (3454552) 3454552..3454926 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MA624_RS16985 (3454954) 3454954..3455172 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MA624_RS16990 (3455351) 3455351..3455902 + 552 WP_001278793.1 maltose O-acetyltransferase -
MA624_RS16995 (3456020) 3456020..3456490 + 471 WP_000136183.1 YlaC family protein -
MA624_RS17000 (3456546) 3456546..3456686 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MA624_RS17005 (3456692) 3456692..3456952 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MA624_RS17010 (3457177) 3457177..3458727 + 1551 WP_000213145.1 EAL domain-containing protein -
MA624_RS17020 (3458958) 3458958..3459347 + 390 WP_023224410.1 MGMT family protein -
MA624_RS17025 (3459380) 3459380..3459949 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T235480 WP_001280991.1 NZ_CP092012:3454954-3455172 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T235480 NZ_CP092012:3454954-3455172 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT235480 WP_000344807.1 NZ_CP092012:3454552-3454926 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT235480 NZ_CP092012:3454552-3454926 [Salmonella enterica subsp. enterica serovar Kentucky]
ATGGACGAATACTCACCCAAAAGACATGATATAGCACAGCTTAAATTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAACCATGGCTGGGTTAATGACCCGACCTCAGCAGTCAACCTGCAGCTCAATGAGCTGATAGAGC
ATATTGCAACTTTCGCGCTTAATTATAAAATTAAGTACAATGAAGACAATAAATTGATTGCGCAGATAGATGAATACCTG
GACGACACCTTTATGTTGTTCAGCAGCTATGGTATTAATACGCAGGATTTGCAAAAATGGCGTAAATCGGGCAACCGCCT
GTTCCGTTGTTTCGTCAACGCCACCAGGGCTAATCCTGTTAGTTTGTCTTGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References