Detailed information of TA system TA235479

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): stbDE/ParE-YafN
• Location: 2463573..2464095
• Replicon: chromosome
• Accession: NZ_CP092012
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain N12-0259

Toxin (Protein)

• Gene name: stbE
• Uniprot ID: V7IL40
• Locus tag: MA624_RS12110
• Protein ID: WP_000221345.1
• Coordinates: 2463811..2464095 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: stbD
• Uniprot ID: V1H457
• Locus tag: MA624_RS12105
• Protein ID: WP_000885424.1
• Coordinates: 2463573..2463821 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA624_RS12075 (2459099)	2459099..2460007	-	909	WP_052939372.1	LysR family transcriptional regulator	-
MA624_RS12080 (2460409)	2460409..2460597	+	189	WP_001276021.1	DUF29 family protein	-
MA624_RS12085 (2460963)	2460963..2461702	+	740	Protein_2366	hypothetical protein	-
MA624_RS12090 (2461704)	2461704..2462612	-	909	WP_077906523.1	hypothetical protein	-
MA624_RS12095 (2462885)	2462885..2463216	-	332	Protein_2368	DUF1493 family protein	-
MA624_RS12100 (2463302)	2463302..2463421	-	120	Protein_2369	type II and III secretion system	-
MA624_RS12105 (2463573)	2463573..2463821	+	249	WP_000885424.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
MA624_RS12110 (2463811)	2463811..2464095	+	285	WP_000221345.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
MA624_RS12115 (2464266)	2464266..2464655	+	390	WP_000194089.1	RidA family protein	-
MA624_RS12120 (2464707)	2464707..2465786	-	1080	WP_023203126.1	S-adenosylmethionine:tRNA ribosyltransferase-isomerase	-
MA624_RS12125 (2465979)	2465979..2466467	-	489	WP_023223899.1	MarR family winged helix-turn-helix transcriptional regulator	-
MA624_RS12130 (2466512)	2466512..2468020	+	1509	WP_023223898.1	FAD-dependent oxidoreductase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	2456227..2470877	14650

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-84)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11043.79 Da
• Isoelectric Point: 10.6500

>T235479 WP_000221345.1 NZ_CP092012:2463811-2464095 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Nucleotide

• Length: 285 bp

>T235479 NZ_LR134293:1504891-1505226 [Streptococcus canis]
TTGGACTATAAGAAATATCAGATTATCTATGCTCCTGATGTTTTAGAGAAGTTAAAGGAAATTCGTGATTATATTTCTCA
AAACTATTCCTCGACATCAGGTCAGCACAAAATGGAGCAAATCATTAGTGACATAGAAAAACTCAAGGTTTTCCCTGAAG
TTGGTTTTGATGCCGATGAAAAATATGGTTCAAAAATCAGTAAGTACCACAGCACTAGAGGTTATACCTTAAGTAAAGAT
TATATTGTCCTATACCATATCGAGGAGGAAGAGAATAGGGTCGTTATTGATTACTTGCTTCCTGCTCGAAGCGACTATAT
CAAATTATTCAAATAG

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9090.32 Da
• Isoelectric Point: 3.9820

>AT235479 WP_000885424.1 NZ_CP092012:2463573-2463821 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Nucleotide

• Length: 249 bp

>AT235479 NZ_LR134293:1504614-1504901 [Streptococcus canis]
ATGGTTGAAGTAGAAAAAAACAGAGCTGTTACATTCCAAGCTAACAAAGAATTGGTAAGCGAAGCAATGACAGTATTAAA
CAAGAAAAATTTAACCTTATCATCTGCTTTAAGATTATTCCTTCAAAATGTCGTTGTCACAAATGAGGTTGACTTATTGA
CGGAAGAGGAGCTAGAGAAAGAAAAACTTTTCAAGCAATTTCAAGCTGAAATCAACAAAAATATTGAAGATGTTCGTCAA
GGGAAATTTTATACCTCTGAAGAAGTGAGGTCTGAACTTGGACTATAA

Structures

Toxin

• AlphaFold DB: A0A5Y2FFA8

Antitoxin

• AlphaFold DB: A0A5I0WPN5