Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1068291..1069105 Replicon chromosome
Accession NZ_CP092012
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N12-0259

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag MA624_RS05275 Protein ID WP_000971653.1
Coordinates 1068291..1068818 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag MA624_RS05280 Protein ID WP_000855694.1
Coordinates 1068815..1069105 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA624_RS05245 (1064665) 1064665..1065063 + 399 Protein_1031 cytoplasmic protein -
MA624_RS05250 (1065274) 1065274..1065492 + 219 Protein_1032 hypothetical protein -
MA624_RS05255 (1065649) 1065649..1066317 + 669 WP_000445914.1 hypothetical protein -
MA624_RS05260 (1066344) 1066344..1066838 + 495 WP_000424946.1 hypothetical protein -
MA624_RS05265 (1067010) 1067010..1067666 - 657 WP_023225036.1 protein-serine/threonine phosphatase -
MA624_RS05270 (1068016) 1068016..1068218 + 203 Protein_1036 IS5/IS1182 family transposase -
MA624_RS05275 (1068291) 1068291..1068818 - 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
MA624_RS05280 (1068815) 1068815..1069105 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
MA624_RS05285 (1069376) 1069376..1069576 - 201 Protein_1039 transposase -
MA624_RS05290 (1069817) 1069817..1070143 + 327 WP_000393295.1 hypothetical protein -
MA624_RS05295 (1070416) 1070416..1070763 - 348 WP_001555786.1 DUF1493 family protein -
MA624_RS05300 (1070748) 1070748..1071197 - 450 WP_023225038.1 hypothetical protein -
MA624_RS05305 (1071629) 1071629..1072072 - 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MA624_RS05310 (1072530) 1072530..1073180 + 651 WP_072203970.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1068042..1069576 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T235470 WP_000971653.1 NZ_CP092012:c1068818-1068291 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T235470 NZ_LR134280:4744102-4744587 [Klebsiella pneumoniae]
ATGATCTCGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTGGTTAAT
GCCTGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT235470 WP_000855694.1 NZ_CP092012:c1069105-1068815 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT235470 NZ_LR134280:4743812-4744105 [Klebsiella pneumoniae]
ATGCCAGCCGCAAACAGCATGTCCATAAAACGCGAAACGTTAAATCTGCGCATTAAACCTGCCGAACGCGATCTTATTGA
TCGGGCGGCGAAAGCCAGAGGGAAAAACCGCACAGACTTTGTGCTGGAGGCCGCCCGCGCTGCCGCTGAGGAAGCGCTGA
TTGAGCAACGCATCATTATGGCCGATCCGCAGGCTTATCAGGAATTTCTCGCTCGTCTGGATCAGGCTCCTGCACCTAAT
GCCGCACTGCGTAAAACTATGCAGACCCCTGCGCCGTGGGAACAGGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References