Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 199198..199958 Replicon chromosome
Accession NZ_CP092012
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N12-0259

Toxin (Protein)


Gene name tacT Uniprot ID A0A5H3Y7E3
Locus tag MA624_RS00960 Protein ID WP_023225088.1
Coordinates 199198..199683 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3Z2K6C6
Locus tag MA624_RS00965 Protein ID WP_072106018.1
Coordinates 199671..199958 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA624_RS00930 (194272) 194272..194934 + 663 WP_000747548.1 OmpA family lipoprotein -
MA624_RS00935 (195153) 195153..196127 + 975 WP_023225087.1 glyoxylate/hydroxypyruvate reductase GhrB -
MA624_RS00940 (196177) 196177..196887 - 711 WP_000190524.1 DUF3053 domain-containing protein -
MA624_RS00945 (197326) 197326..197616 + 291 WP_000455790.1 HTH-type transcriptional regulator -
MA624_RS00950 (197904) 197904..198116 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MA624_RS00955 (198289) 198289..198828 + 540 WP_000047141.1 copper-binding periplasmic metallochaperone CueP -
MA624_RS00960 (199198) 199198..199683 - 486 WP_023225088.1 GNAT family N-acetyltransferase Toxin
MA624_RS00965 (199671) 199671..199958 - 288 WP_072106018.1 DUF1778 domain-containing protein Antitoxin
MA624_RS00970 (200081) 200081..201109 - 1029 WP_023196719.1 HNH endonuclease signature motif containing protein -
MA624_RS00975 (202136) 202136..202906 + 771 WP_000456879.1 DUF3800 domain-containing protein -
MA624_RS00980 (203102) 203102..203530 - 429 Protein_191 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.0965

>T235468 WP_023225088.1 NZ_CP092012:c199683-199198 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T235468 NZ_LR134280:c3958571-3958188 [Klebsiella pneumoniae]
ATGACCTCCGGATCTGCGCTTTTTGATACCAATATTCTTATTGATTTATTTAGCGGGCGTCGCGAAGCCAAACAGGCGCT
GGAGGCCTGGCCACCGCAGAATGCGATCAGTCTGATTACCTGGATGGAGGTGATGGTTGGCGCTAAAAAATATCACCAGG
AGCAGCGCACGCGAATGGCGCTGAGCACCTTTAATATCATTAACATCTCACAGGATATTGCAGAGCGAAGCGTTGCGCTG
CGGCAGGAGTATAAGCTTAAGCTGCCGGATGCCATCATTCTGGCGACGGCGCAACTCCATCGTCTGGAACTAATTACGCG
GAATACGAAGGATTTTGCCGGTATTCCTGGCGTAGTCACGCCGTACGAAATCCACCCTGAATAA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10982.66 Da        Isoelectric Point: 4.6811

>AT235468 WP_072106018.1 NZ_CP092012:c199958-199671 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM

Download         Length: 288 bp

>AT235468 NZ_LR134280:c3958813-3958571 [Klebsiella pneumoniae]
ATGATGGCTGAAAGGGATATGGGCAGAATTCTTCTCGATTTATCAGACGATGTCATTCAACGTCTCGATGACCTCAAAGT
GCAGCGTAACATTCCGCGAGCGGAACTGTTACGTGAAGCGGTTGAACAATATCTGGAGAAACAAGATCGAGCTAAAGATA
CCATCTCCAGTGCGCTGGGTCTGTGGCAAGACTGCGAAGAAGACGGCATGGAATATCAACGTCAGCTACGCAAGGAGTGG
TAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H3Y7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z2K6C6

References