235464

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 4291299..4292080 Replicon chromosome
Accession NZ_CP092009
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N12-0931

Toxin (Protein)


Gene name TacT2 Uniprot ID A0A3G3E5T9
Locus tag MA811_RS20820 Protein ID WP_000625911.1
Coordinates 4291299..4291790 (-) Length 164 a.a.

Antitoxin (Protein)


Gene name TacA2 Uniprot ID V7IUD2
Locus tag MA811_RS20825 Protein ID WP_001271379.1
Coordinates 4291787..4292080 (-) Length 98 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA811_RS20795 (4286435) 4286435..4288873 - 2439 WP_023224120.1 F4 (K88) fimbrial usher FaeD -
MA811_RS20800 (4288883) 4288883..4289422 - 540 WP_000721295.1 type 1 fimbrial protein -
MA811_RS20805 (4289457) 4289457..4289747 - 291 WP_000773469.1 PapB/FocB family fimbrial expression transcriptional regulator -
MA811_RS20810 (4290334) 4290334..4290561 + 228 WP_001112992.1 hypothetical protein -
MA811_RS20815 (4290836) 4290836..4291084 - 249 Protein_4074 IS481 family transposase -
MA811_RS20820 (4291299) 4291299..4291790 - 492 WP_000625911.1 GNAT family N-acetyltransferase Toxin
MA811_RS20825 (4291787) 4291787..4292080 - 294 WP_001271379.1 DUF1778 domain-containing protein Antitoxin
MA811_RS20830 (4292398) 4292398..4292619 + 222 WP_052939504.1 hypothetical protein -
MA811_RS20835 (4292885) 4292885..4293760 + 876 WP_023205266.1 AraC family transcriptional regulator -
MA811_RS20840 (4293757) 4293757..4294044 + 288 WP_072103482.1 transcriptional regulator RtsB -
MA811_RS20845 (4294037) 4294037..4294219 - 183 WP_072106065.1 ATP-binding cassette domain-containing protein -
MA811_RS20850 (4294239) 4294239..4294338 + 100 Protein_4081 hypothetical protein -
MA811_RS20855 (4294386) 4294386..4294580 + 195 WP_223163373.1 hypothetical protein -
MA811_RS20860 (4294875) 4294875..4295780 - 906 WP_001268192.1 YjiK family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - faeI / faeH / faeF / faeE / faeD / faeC 4278277..4294219 15942


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(87-144)

Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 164 a.a.        Molecular weight: 17663.44 Da        Isoelectric Point: 7.2655

>T235464 WP_000625911.1 NZ_CP092009:c4291790-4291299 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Download         Length: 492 bp

>T235464 NZ_LR134280:2730036-2730254 [Klebsiella pneumoniae]
ATGTCTGATAAGCCATTAACTAAAACAGACTATTTGATGCGCTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGCGT
CATTGAAAAAAATAAATATGAACTGTCTGATAATGAGCTGGCGGTATTTTACTCAGCTGCCGACCATCGTCTGGCGGAAC
TGACCATGAATAAGCTATACGATAAAATCCCGACTTCTGTCTGGAAATTTATCCGCTAA

Antitoxin


Download         Length: 98 a.a.        Molecular weight: 10938.54 Da        Isoelectric Point: 9.8590

>AT235464 WP_001271379.1 NZ_CP092009:c4292080-4291787 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Download         Length: 294 bp

>AT235464 NZ_LR134280:2729635-2730009 [Klebsiella pneumoniae]
ATGGACGAATACTCGCCAAAAAGACATGATATTGCACAGCTACGCTTTCTCTGCGAAACGCTGTATCATGACTGCCTTGC
AAACCTGGAAGAGAGCAACCATGGCTGGGTCAACGACCCGACGTCGGCTGTCAATCTCCAGTTAAATGAATTGATCGAGC
ACATTGCCACATTCGCTCTTAATTATAAAATTAAGTATGCAGAGGATAATAAGCTGATCGCTCAGGTTGACGAATATCTG
GACGACACTTTTACGTTGTTCAGTAACTACGGCATTAACTCTACGGATTTGCAAAAGTGGAAAAAATCCGGTAACCGACT
ATTTCGTTGCTTTGTCAACGCCAGCCGGGAAAACCCGGCCAGTCTATCGTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3E5T9

Antitoxin

Source ID Structure
AlphaFold DB V7IUD2

References