Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3420199..3420819 Replicon chromosome
Accession NZ_CP092009
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N12-0931

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MA811_RS16740 Protein ID WP_001280991.1
Coordinates 3420601..3420819 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MA811_RS16735 Protein ID WP_000344807.1
Coordinates 3420199..3420573 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA811_RS16725 (3415338) 3415338..3416531 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MA811_RS16730 (3416554) 3416554..3419703 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MA811_RS16735 (3420199) 3420199..3420573 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MA811_RS16740 (3420601) 3420601..3420819 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MA811_RS16745 (3420998) 3420998..3421549 + 552 WP_001278793.1 maltose O-acetyltransferase -
MA811_RS16750 (3421667) 3421667..3422137 + 471 WP_000136183.1 YlaC family protein -
MA811_RS16755 (3422193) 3422193..3422333 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MA811_RS16760 (3422339) 3422339..3422599 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MA811_RS16765 (3422824) 3422824..3424374 + 1551 WP_000213145.1 EAL domain-containing protein -
MA811_RS16775 (3424605) 3424605..3424994 + 390 WP_023224410.1 MGMT family protein -
MA811_RS16780 (3425027) 3425027..3425596 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T235459 WP_001280991.1 NZ_CP092009:3420601-3420819 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T235459 NZ_LR134271:c2583204-2582938 [Staphylococcus aureus]
ATGAGCAATTACACGGTTAAGATTAAAAATTCAGCGAAATCAGATTTAAAGAAAATAAAACATTCTTATTTAAAGAAGTC
ATTTTTAGAAATTGTTGAGACTTTAAAAAATGATCCGTATAAAATAACACAATCCTTTGAAAAATTAGAACCTAAATATT
TAGAGCGATATTCAAGAAGAATTAACCATCAGCACAGGGTCGTCTATACCGTAGATGATCGAAATAAAGAAGTATTGATA
CTATCGGCATGGTCACATTATGATTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT235459 WP_000344807.1 NZ_CP092009:3420199-3420573 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT235459 NZ_LR134271:c2583461-2583204 [Staphylococcus aureus]
ATGATTATCACTAGCCCTACAGAAGCGAGAAAAGATTTTTATCAATTACTAAAAAATGTTAATAATAATCACGAACCAAT
TTATATTAGTGGCAATAATGCCGAAAATAATGCTGTGATTATAGGTTTAGAAGATTGGAAAAGTATACAAGAGACAATAT
ATCTTGAATCTACTGGTACAATGGACAAAGTAAGAGAAAGAGAAAAAGATAGTAGTGGTACAACAAATATAGATGATATT
GATTGGGATAATCTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References