Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2429217..2429739 Replicon chromosome
Accession NZ_CP092009
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N12-0931

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag MA811_RS11865 Protein ID WP_000221345.1
Coordinates 2429455..2429739 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MA811_RS11860 Protein ID WP_000885424.1
Coordinates 2429217..2429465 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA811_RS11830 (2424743) 2424743..2425651 - 909 WP_052939372.1 LysR family transcriptional regulator -
MA811_RS11835 (2426053) 2426053..2426241 + 189 WP_001276021.1 DUF29 family protein -
MA811_RS11840 (2426607) 2426607..2427346 + 740 Protein_2318 hypothetical protein -
MA811_RS11845 (2427348) 2427348..2428256 - 909 WP_077906523.1 hypothetical protein -
MA811_RS11850 (2428529) 2428529..2428860 - 332 Protein_2320 DUF1493 family protein -
MA811_RS11855 (2428946) 2428946..2429065 - 120 Protein_2321 type II and III secretion system -
MA811_RS11860 (2429217) 2429217..2429465 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MA811_RS11865 (2429455) 2429455..2429739 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MA811_RS11870 (2429910) 2429910..2430299 + 390 WP_000194089.1 RidA family protein -
MA811_RS11875 (2430351) 2430351..2431430 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MA811_RS11880 (2431623) 2431623..2432111 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
MA811_RS11885 (2432156) 2432156..2433664 + 1509 WP_023223898.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2421871..2436521 14650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T235458 WP_000221345.1 NZ_CP092009:2429455-2429739 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T235458 NZ_LR134271:c2551802-2551695 [Staphylococcus aureus]
ATGTTCAATTTATTAATTGACATCATGACTTCAGCTTTAAGCGGCTGTCTTGTTGCGTTTTTTGCACATTGGTTACGAAC
GCGCAACAATAAAAAAGGTGACAAATAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT235458 WP_000885424.1 NZ_CP092009:2429217-2429465 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT235458 NZ_LR134271:2551618-2551678 [Staphylococcus aureus]
TACATAATAAATTGAACATCTAAATACACCAAATCCCCTCACTACTGCCATAGTGAGGGGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References