Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | tacAT/DUF1778(antitoxin) |
| Location | 1032833..1033647 | Replicon | chromosome |
| Accession | NZ_CP092009 | ||
| Organism | Salmonella enterica subsp. enterica serovar Kentucky strain N12-0931 | ||
Toxin (Protein)
| Gene name | TacT3 | Uniprot ID | A0A3G3DUX8 |
| Locus tag | MA811_RS05040 | Protein ID | WP_000971653.1 |
| Coordinates | 1032833..1033360 (-) | Length | 176 a.a. |
Antitoxin (Protein)
| Gene name | TacA3 | Uniprot ID | M7S6I2 |
| Locus tag | MA811_RS05045 | Protein ID | WP_000855694.1 |
| Coordinates | 1033357..1033647 (-) | Length | 97 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| MA811_RS05010 (1029207) | 1029207..1029605 | + | 399 | Protein_984 | cytoplasmic protein | - |
| MA811_RS05015 (1029816) | 1029816..1030034 | + | 219 | Protein_985 | hypothetical protein | - |
| MA811_RS05020 (1030191) | 1030191..1030859 | + | 669 | WP_000445914.1 | hypothetical protein | - |
| MA811_RS05025 (1030886) | 1030886..1031380 | + | 495 | WP_000424946.1 | hypothetical protein | - |
| MA811_RS05030 (1031552) | 1031552..1032208 | - | 657 | WP_023225036.1 | protein-serine/threonine phosphatase | - |
| MA811_RS05035 (1032558) | 1032558..1032760 | + | 203 | Protein_989 | IS5/IS1182 family transposase | - |
| MA811_RS05040 (1032833) | 1032833..1033360 | - | 528 | WP_000971653.1 | GNAT family N-acetyltransferase | Toxin |
| MA811_RS05045 (1033357) | 1033357..1033647 | - | 291 | WP_000855694.1 | DUF1778 domain-containing protein | Antitoxin |
| MA811_RS05050 (1033918) | 1033918..1034118 | - | 201 | Protein_992 | transposase | - |
| MA811_RS05055 (1034359) | 1034359..1034685 | + | 327 | WP_000393295.1 | hypothetical protein | - |
| MA811_RS05060 (1034958) | 1034958..1035305 | - | 348 | WP_001555786.1 | DUF1493 family protein | - |
| MA811_RS05065 (1035290) | 1035290..1035739 | - | 450 | WP_023225038.1 | hypothetical protein | - |
| MA811_RS05070 (1036171) | 1036171..1036614 | - | 444 | WP_023225039.1 | SPI-1 type III secretion system invasion lipoprotein InvH | - |
| MA811_RS05075 (1037072) | 1037072..1037722 | + | 651 | WP_072203970.1 | type III secretion system transcriptional activator InvF | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | IScluster/Tn | - | - | 1032584..1034118 | 1534 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 176 a.a. Molecular weight: 19043.87 Da Isoelectric Point: 9.7032
>T235449 WP_000971653.1 NZ_CP092009:c1033360-1032833 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL
Download Length: 528 bp
>T235449 NZ_LR134270:c3812562-3812158 [Escherichia marmotae]
GTGGTCCTGTGGCAATCTGAATTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCCTGCTGATTCATGGGCTGGTTGCCGC
AGTTATTTTACTCATGCCATGGCCACTTAGTTACACCCCGCTATGGCTGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATTCCCGTCAGGGAGAGATTCGCCTGCTGATGGATTGGCGTTTACGTTGGCAAGGACAG
GAATGGAGCATCGTCAAAACGCCGTGGATGATTAAAAGCGGCATGATGTTACGTTTACGTTCTGATAGCGGAAAACGTCA
GCATTTGTGGCTGGCAGCAGACAGCATGGACGAAGCCGAATGGCGTGATTTACGGCGAATTGTGTTACAGCAAGAGATAC
GATGA
GTGGTCCTGTGGCAATCTGAATTACGCGTCTCCTGGCGCGCGCAGTGGCTTTCCCTGCTGATTCATGGGCTGGTTGCCGC
AGTTATTTTACTCATGCCATGGCCACTTAGTTACACCCCGCTATGGCTGGTGTTGCTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGACGCATTAATTCCCGTCAGGGAGAGATTCGCCTGCTGATGGATTGGCGTTTACGTTGGCAAGGACAG
GAATGGAGCATCGTCAAAACGCCGTGGATGATTAAAAGCGGCATGATGTTACGTTTACGTTCTGATAGCGGAAAACGTCA
GCATTTGTGGCTGGCAGCAGACAGCATGGACGAAGCCGAATGGCGTGATTTACGGCGAATTGTGTTACAGCAAGAGATAC
GATGA
Antitoxin
Download Length: 97 a.a. Molecular weight: 10664.50 Da Isoelectric Point: 6.3133
>AT235449 WP_000855694.1 NZ_CP092009:c1033647-1033357 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK
Download Length: 291 bp
>AT235449 NZ_LR134270:c3812809-3812543 [Escherichia marmotae]
ATGGATATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGCGGTATGCGTGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGCGACGATCCGGACC
TGTTCAACTGGCTGATGAATCATGGTAAACCTGCCGATGCAGAACTGGAAATGATGGTCAGACTCATTCAGACACGGAAC
CGGGATCGTGGTCCTGTGGCAATCTGA
ATGGATATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGCGGTATGCGTGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGCGACGATCCGGACC
TGTTCAACTGGCTGATGAATCATGGTAAACCTGCCGATGCAGAACTGGAAATGATGGTCAGACTCATTCAGACACGGAAC
CGGGATCGTGGTCCTGTGGCAATCTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3G3DUX8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3V8SJE7 |