Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 864898..865558 Replicon chromosome
Accession NZ_CP092009
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N12-0931

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MA811_RS04275 Protein ID WP_000244756.1
Coordinates 865145..865558 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MA811_RS04270 Protein ID WP_000351186.1
Coordinates 864898..865164 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA811_RS04250 (860827) 860827..862260 - 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -
MA811_RS04255 (862418) 862418..862729 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MA811_RS04260 (862893) 862893..863552 + 660 WP_000250289.1 hemolysin III family protein -
MA811_RS04265 (863668) 863668..864648 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
MA811_RS04270 (864898) 864898..865164 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MA811_RS04275 (865145) 865145..865558 + 414 WP_000244756.1 protein YgfX Toxin
MA811_RS04280 (865611) 865611..866132 - 522 WP_001055885.1 flavodoxin FldB -
MA811_RS04285 (866245) 866245..867141 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MA811_RS04290 (867165) 867165..867878 + 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MA811_RS04295 (867884) 867884..869617 + 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T235448 WP_000244756.1 NZ_CP092009:865145-865558 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T235448 NZ_LR134270:2724870-2724977 [Escherichia marmotae]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTTGCGGGAATTATCACCGCAGCGAT
TGTCGGCTGGTGGCGTAACCGGAAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT235448 WP_000351186.1 NZ_CP092009:864898-865164 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235448 NZ_LR134270:c2724810-2724755 [Escherichia marmotae]
CAAGATTAGCCCCCGTTCTGTTGTCAGGTTTGACCTCTCAACGTGCGGGGGTTTTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References