Detailed information of TA system TA235443

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tacAT/DUF1778(antitoxin)
• Location: 4328286..4329067
• Replicon: chromosome
• Accession: NZ_CP092004
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain N14-1660

Toxin (Protein)

• Gene name: TacT2
• Uniprot ID: A0A3G3E5T9
• Locus tag: MA620_RS21090
• Protein ID: WP_000625911.1
• Coordinates: 4328286..4328777 (-)
• Length: 164 a.a.

Antitoxin (Protein)

• Gene name: TacA2
• Uniprot ID: V7IUD2
• Locus tag: MA620_RS21095
• Protein ID: WP_001271379.1
• Coordinates: 4328774..4329067 (-)
• Length: 98 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA620_RS21065 (4323422)	4323422..4325860	-	2439	WP_023224120.1	F4 (K88) fimbrial usher FaeD	-
MA620_RS21070 (4325870)	4325870..4326409	-	540	WP_000721295.1	type 1 fimbrial protein	-
MA620_RS21075 (4326444)	4326444..4326734	-	291	WP_000773469.1	PapB/FocB family fimbrial expression transcriptional regulator	-
MA620_RS21080 (4327321)	4327321..4327548	+	228	WP_001112992.1	hypothetical protein	-
MA620_RS21085 (4327823)	4327823..4328071	-	249	Protein_4125	IS481 family transposase	-
MA620_RS21090 (4328286)	4328286..4328777	-	492	WP_000625911.1	GNAT family N-acetyltransferase	Toxin
MA620_RS21095 (4328774)	4328774..4329067	-	294	WP_001271379.1	DUF1778 domain-containing protein	Antitoxin
MA620_RS21100 (4329385)	4329385..4329606	+	222	WP_052939504.1	hypothetical protein	-
MA620_RS21105 (4329872)	4329872..4330747	+	876	WP_023205266.1	AraC family transcriptional regulator	-
MA620_RS21110 (4330744)	4330744..4331031	+	288	WP_072103482.1	transcriptional regulator RtsB	-
MA620_RS21115 (4331024)	4331024..4331206	-	183	WP_072106065.1	ATP-binding cassette domain-containing protein	-
MA620_RS21120 (4331226)	4331226..4331325	+	100	Protein_4132	hypothetical protein	-
MA620_RS21125 (4331373)	4331373..4331567	+	195	WP_223163373.1	hypothetical protein	-
MA620_RS21130 (4331862)	4331862..4332767	-	906	WP_001268192.1	YjiK family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	faeI / faeH / faeF / faeE / faeD / faeC	4316163..4331206	15043

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (87-144)

Antitoxin

• Vibrio phage ICP1, Orf50 (1-95)

Sequences

Toxin

Protein

• Length: 164 a.a.
• Molecular weight: 17663.44 Da
• Isoelectric Point: 7.2655

>T235443 WP_000625911.1 NZ_CP092004:c4328777-4328286 [Salmonella enterica subsp. enterica serovar Kentucky]
MISSPEPLHAGHILTPFCCGVDSMDNWLKQRAMKNQTTGASRTFVCCGSDSNVLAYYSLASSAVTTNTAPGRFRRNMPDP
IPIVVLGRLAVDKSLHGQGVGRALVRDAGLRVIQVAETIGIRGMLVHALSDEAREFYQRVGFEPSPMDPMMLMVTLGDLV
ESV

Nucleotide

• Length: 492 bp

>T235443 NZ_LR134270:c1906842-1906555 [Escherichia marmotae]
ATGTTACCCATTTTATGGCTACCATCTGCTCGCGATGATTTGCGTCAGATCGTAGCCTATATTGCTAAGGAAAATATTCC
TGCAGCACGCAGACTAAAAATACGTATTGAAACGTCTGTTTTAGCCCTCTCCGAGCATCCATATCTATATCCGCCAAGTG
ATCGAGTATCCGGTTTGCGGGAAATTGTGGTTCACCCTAATTATATCGTTTTGTACCGAGTAGCAGCTTCAAGCATTGAA
ATTGCAAATATTGTGCATGCCCGCCGACAATTTCCCTTCCCTATCTGA

Antitoxin

Protein

• Length: 98 a.a.
• Molecular weight: 10938.54 Da
• Isoelectric Point: 9.8590

>AT235443 WP_001271379.1 NZ_CP092004:c4329067-4328774 [Salmonella enterica subsp. enterica serovar Kentucky]
MSAANSMAMKRETLNLRIKPAERDLIDRAAKARGKNRTDFVLEAARAAAEEALIEQRIIMADPQAYQEFLARLDQTPSPN
AALRKTMQTPAPWEQEK

Nucleotide

• Length: 294 bp

>AT235443 NZ_LR134270:c1907033-1906842 [Escherichia marmotae]
ATGAGTACAGCCCTTTCTCCGATAGTTTCAGAATTCGAAACTACCGAACAAGAAAACAGTTACAACGAATGGTTGCGCGC
TAAAGTGGCGTCAAGCCTTGCAGACCCTCGTCCCTCAATTCCACATGACGAGGTAATGGCTGAAATAGAAAATCTTATTG
CTCAAATTGCTGTAACTAACAGGAGCGAGTAA

Structures

Toxin

• AlphaFold DB: A0A3G3E5T9

Antitoxin

• AlphaFold DB: V7IUD2