235442

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4190100..4190743 Replicon chromosome
Accession NZ_CP092004
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N14-1660

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag MA620_RS20360 Protein ID WP_000048134.1
Coordinates 4190327..4190743 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag MA620_RS20355 Protein ID WP_001261294.1
Coordinates 4190100..4190330 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA620_RS20345 (4187113) 4187113..4189251 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MA620_RS20350 (4189468) 4189468..4189932 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MA620_RS20355 (4190100) 4190100..4190330 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MA620_RS20360 (4190327) 4190327..4190743 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
MA620_RS20365 (4190804) 4190804..4192717 - 1914 WP_001212148.1 BglG family transcription antiterminator -
MA620_RS20370 (4192734) 4192734..4193474 - 741 WP_000779255.1 KDGP aldolase family protein -
MA620_RS20375 (4193471) 4193471..4194589 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MA620_RS20380 (4194573) 4194573..4195706 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T235442 WP_000048134.1 NZ_CP092004:4190327-4190743 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T235442 NZ_LR134270:c1293067-1292849 [Escherichia marmotae]
ATGTCCGATAAACCTTTAACAAAAACCGATTATTTGATGCGTTTGCGTCGTTGTCAGACAATTGACACGCTGGAACGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTTGCAGAAT
TGACCATGAATAAACTTTACGACAAGATCCCTTCCTCGGTGTGGAAATTTATTCGATAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT235442 WP_001261294.1 NZ_CP092004:4190100-4190330 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT235442 NZ_LR134270:c1293467-1293072 [Escherichia marmotae]
ATGGATGAATACTCACCAAAAAGACATGATATTGCACAGCTTAAGTTTCTTTGCGAAACCCTGTATCATGACTGTCTTGC
AAACCTTGAAGAAAGCAATCATGGTTGGGTTAACGACCCTACCTCGGCTATCAATCTGCAACTTAATGAACTCATTGAGC
ATATTGCAACCTTCGCGCTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATAGATGAATATCTG
GACGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTCCAGAAATGGCGGAAGTCAGGTAACCGACT
GTTCCGTTGTTTCGTGAATGCCACGAAAGAGAATCCTGCAAGTTTATCTTGTTCGAATTATTACAACCATGGGTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References