Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3456957..3457577 Replicon chromosome
Accession NZ_CP092004
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N14-1660

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MA620_RS17000 Protein ID WP_001280991.1
Coordinates 3457359..3457577 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MA620_RS16995 Protein ID WP_000344807.1
Coordinates 3456957..3457331 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA620_RS16985 (3452096) 3452096..3453289 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MA620_RS16990 (3453312) 3453312..3456461 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MA620_RS16995 (3456957) 3456957..3457331 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MA620_RS17000 (3457359) 3457359..3457577 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MA620_RS17005 (3457756) 3457756..3458307 + 552 WP_001278793.1 maltose O-acetyltransferase -
MA620_RS17010 (3458425) 3458425..3458895 + 471 WP_000136183.1 YlaC family protein -
MA620_RS17015 (3458951) 3458951..3459091 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MA620_RS17020 (3459097) 3459097..3459357 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MA620_RS17025 (3459582) 3459582..3461132 + 1551 WP_000213145.1 EAL domain-containing protein -
MA620_RS17035 (3461363) 3461363..3461752 + 390 WP_023224410.1 MGMT family protein -
MA620_RS17040 (3461785) 3461785..3462354 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T235438 WP_001280991.1 NZ_CP092004:3457359-3457577 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T235438 NZ_LR134269:1908654-1908839 [Staphylococcus warneri]
ATGAGCTTGCATTTTACAATTCTTTTTTGGCTTTCACTTATATTTATCGTAGCTGGTGCGATTATTCTAGCTATCATGCT
TAAAACTAAAAAAGAATCTAAGAAAGAATCTTATCTTGGTTTCACCATTGTATTCTTCATTTTTGGATTAGCTATGTTGA
TATATACATTGTTATTCGGACTCTAG

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT235438 WP_000344807.1 NZ_CP092004:3456957-3457331 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT235438 NZ_LR134269:1908377-1908634 [Staphylococcus warneri]
ATGAAACTATACATTATACATGCAATCAATATTATTTTAACGATATTATTTATTATTTTTAATGTAATTATTACTTATAA
TGCAAACCTAGACGATACCTTATGGTTAGTGCCTGGATTAATTGTATGCGGTTTGATTATGATGATTAGTTTTGCTATTG
CTATAACTAAAAAGGACTTGTTAAGTGAAGTTCTTTTCTTTATTAATATTATTCTTACACTGTACTACATTTATCCAATT
TTTTATGATTTTCTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References