235437

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2464718..2465240 Replicon chromosome
Accession NZ_CP092004
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N14-1660

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag MA620_RS12120 Protein ID WP_000221345.1
Coordinates 2464956..2465240 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MA620_RS12115 Protein ID WP_000885424.1
Coordinates 2464718..2464966 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA620_RS12085 (2460244) 2460244..2461152 - 909 WP_052939372.1 LysR family transcriptional regulator -
MA620_RS12090 (2461554) 2461554..2461742 + 189 WP_001276021.1 DUF29 family protein -
MA620_RS12095 (2462108) 2462108..2462847 + 740 Protein_2368 hypothetical protein -
MA620_RS12100 (2462849) 2462849..2463757 - 909 WP_077906523.1 hypothetical protein -
MA620_RS12105 (2464030) 2464030..2464361 - 332 Protein_2370 DUF1493 family protein -
MA620_RS12110 (2464447) 2464447..2464566 - 120 Protein_2371 type II and III secretion system -
MA620_RS12115 (2464718) 2464718..2464966 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MA620_RS12120 (2464956) 2464956..2465240 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MA620_RS12125 (2465411) 2465411..2465800 + 390 WP_000194089.1 RidA family protein -
MA620_RS12130 (2465852) 2465852..2466931 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MA620_RS12135 (2467124) 2467124..2467612 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
MA620_RS12140 (2467657) 2467657..2469165 + 1509 WP_023223898.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - - 2457372..2472022 14650


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T235437 WP_000221345.1 NZ_CP092004:2464956-2465240 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T235437 NZ_LR134269:960807-960902 [Staphylococcus warneri]
ATGACTGAAATCTTTGTTCATATCGCAACTACTGTTATTAGTGGTTGTATCGTTACATTATTTGCGCAATGGCTACGCCA
TCGTAACGACAAGTAA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT235437 WP_000885424.1 NZ_CP092004:2464718-2464966 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT235437 NZ_LR134269:c960968-960934 [Staphylococcus warneri]
ACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References