Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1020806..1021566 Replicon chromosome
Accession NZ_CP092004
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N14-1660

Toxin (Protein)


Gene name tacT Uniprot ID A0A5H3Y7E3
Locus tag MA620_RS05045 Protein ID WP_023225088.1
Coordinates 1020806..1021291 (-) Length 162 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID A0A3Z2K6C6
Locus tag MA620_RS05050 Protein ID WP_072106018.1
Coordinates 1021279..1021566 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA620_RS05015 (1015880) 1015880..1016542 + 663 WP_000747548.1 OmpA family lipoprotein -
MA620_RS05020 (1016761) 1016761..1017735 + 975 WP_023225087.1 glyoxylate/hydroxypyruvate reductase GhrB -
MA620_RS05025 (1017785) 1017785..1018495 - 711 WP_000190524.1 DUF3053 domain-containing protein -
MA620_RS05030 (1018934) 1018934..1019224 + 291 WP_000455790.1 HTH-type transcriptional regulator -
MA620_RS05035 (1019512) 1019512..1019724 + 213 WP_000014594.1 RNA chaperone/antiterminator CspA -
MA620_RS05040 (1019897) 1019897..1020436 + 540 WP_000047141.1 copper-binding periplasmic metallochaperone CueP -
MA620_RS05045 (1020806) 1020806..1021291 - 486 WP_023225088.1 GNAT family N-acetyltransferase Toxin
MA620_RS05050 (1021279) 1021279..1021566 - 288 WP_072106018.1 DUF1778 domain-containing protein Antitoxin
MA620_RS05055 (1021689) 1021689..1022717 - 1029 WP_023196719.1 HNH endonuclease signature motif containing protein -
MA620_RS05060 (1023744) 1023744..1024514 + 771 WP_000456879.1 DUF3800 domain-containing protein -
MA620_RS05065 (1024710) 1024710..1025138 - 429 Protein_990 IS3 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(31-152)

Antitoxin

Vibrio phage ICP1, Orf50

(13-89)


Sequences

Toxin        


Download         Length: 162 a.a.        Molecular weight: 17756.43 Da        Isoelectric Point: 9.0965

>T235428 WP_023225088.1 NZ_CP092004:c1021291-1020806 [Salmonella enterica subsp. enterica serovar Kentucky]
VGHVTAPEPLSAFHQVAEFVSGEAVLDDWLKQKGLKNQALGAARTFVVCKKDTKQVAGFYSLATGSVNHTEATGNLRRNM
PDPIPVIILARLAVDLSFHEKGLGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKNFYIHHGFKSSQTQQRTLFLRLP
Q

Download         Length: 486 bp

>T235428 NZ_LR134265:1099870-1100646 [Streptococcus agalactiae]
ATGGCTCTGGCAGACTATCATCAAGATGACTTTGACTTTGCCTTAAAACGAACCATTCGTTCTTTAACTCGTGGCAAAGA
GACATCAGTTAATCCAAATGCAATTTTACTTGGCGGACAAAGCGGAGCAGGTAAAACAACGATACACCGTATCAAGCAGA
AAGAGTTTCAAGGGAATATCGTCATTATAGACGGTGATAGTTATCGCTCTTTACACCCGAACTATCTAGCTTTACAAGAA
GAATACAGTAAAGATAGCGTGGATTATACCAAAGGTTTTGCAGGAAAAATGGTGGAACATCTTGTCGATGAACTCAGCAA
GCAAGGTTATCATTTATTAATTGAAGGAACCTTGAGAACGGCAGAAGTCCGACGAAAAACAGCTCAGTTATTGAAATCAA
GAGGCTATCAAGTCTCGTTAGCTTTGATAGCAACCAAACCTGAATTGTCCTATCTCAGCACCTTAATCCGCTACGAAGAA
GTCTATGCGGTTAATCCAAACCAAGCTAGAGCAACTCCTAAAGAACATCATGATGCTATTGTAGAGCATTTAGTTGATAA
CTTACGAGAGTTAGAAACTGATAAACTCTTTGACCAGATTCAAATTTATCAAAGAGACAGACGTTGTGTCTATGATTCTG
AAACAGATAAAGGTTCAGCAGCCGATGTCCTACAAGAATGCCTCTTCGGAAAATGGAGCAAGGTAGAGGAGGAGATGATG
AAGGTGGGACAGGAACAGTTGAGGGAAGTAGGTAGAAGGAATGAAAAAGATGCATAG

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10982.66 Da        Isoelectric Point: 4.6811

>AT235428 WP_072106018.1 NZ_CP092004:c1021566-1021279 [Salmonella enterica subsp. enterica serovar Kentucky]
MLYKGCLMKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILETACQAAEKVILDRRVFNFNDEQYEEFINLLDAPVADD
PVIEKLLARKPQWDM

Download         Length: 288 bp

>AT235428 NZ_LR134265:1099394-1099870 [Streptococcus agalactiae]
ATGATTGGAGAGAATATCAAATCGTTACGTAAAACCCATGATTTAACACAACCAGAATTCGCAAAGATTGTTGGAATTTC
ACGAAATAGCCTTAGCCGTTATGAAAATGGTACGAGTTCAGTCACAACAGAACTTATAGACTGCATTTGTCAGAAATTCA
ATGTTTCTTATGTTGATATTGTAGGAGAAGAGAAGATGTTAACACCAGTAGAAGATTATCAATTGACGCTAAAAATAGAA
GTCATCAAAGAGCGTGGCGCAGCGATTTTATCTCAACTATATCGCTATCAAGATAGTCAAGGAATCGCTTTTGACGATGA
GACCAATCCTTGGATTTTAATGAGTGATGACTTGTCAGACCTTATCAATACCAAGATTTACCTTGTTAATACGTTTGATG
AAGTGGAGCGTTACAATGGTTATTTGGATGGTATTGAGCGCATGTTGGTACTTGCTCGTCATCAGGTGGTGGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H3Y7E3

Antitoxin

Source ID Structure
AlphaFold DB A0A3Z2K6C6

References