235427

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 916746..917537 Replicon chromosome
Accession NZ_CP092004
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N14-1660

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag MA620_RS04580 Protein ID WP_000369560.1
Coordinates 916746..917264 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag MA620_RS04585 Protein ID WP_001275017.1
Coordinates 917268..917537 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA620_RS04555 (911811) 911811..912578 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
MA620_RS04560 (912575) 912575..913852 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
MA620_RS04565 (913849) 913849..914775 - 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
MA620_RS04570 (914835) 914835..915944 - 1110 WP_023224165.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
MA620_RS04575 (916366) 916366..916749 + 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
MA620_RS04580 (916746) 916746..917264 - 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
MA620_RS04585 (917268) 917268..917537 - 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
MA620_RS04590 (917715) 917715..918818 - 1104 WP_001533929.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
MA620_RS04595 (919140) 919140..919994 - 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
MA620_RS04600 (920240) 920240..921295 - 1056 WP_001081707.1 permease-like cell division protein FtsX -
MA620_RS04605 (921288) 921288..921956 - 669 WP_000617729.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T235427 WP_000369560.1 NZ_CP092004:c917264-916746 [Salmonella enterica subsp. enterica serovar Kentucky]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

>T235427 NZ_LR134265:c496585-496331 [Streptococcus agalactiae]
ATGTTTAATTTTACTGAAGAAGCATGGAAAGATTATGTTTCTTGGCAACAGGAAGATAAAAAAATCTTGAAACGAATTAA
TCGTTTGATAGAAGATATTAAAAGAGACCCATTTGAAGGCATTGGAAAACCAGAACCTTTAAAATACCATTATTCAGGGG
CTTGGTCTCGAAGAATTACAGAAGAACATAGGTTGATTTATATGATAGAAGATGGAGAAATCTATTTTTTATCTTTTAGA
GATCATTATAAGTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT235427 WP_001275017.1 NZ_CP092004:c917537-917268 [Salmonella enterica subsp. enterica serovar Kentucky]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp

>AT235427 NZ_LR134265:c496844-496578 [Streptococcus agalactiae]
ATGGAGGCTATTGTTTATTCACATTTTAGAAATAATTTAAAAGATTATATGAAGAAGGTCAATGATGAATTTGAGCCTTT
GATTGTAGTTAATAAAAATCCTGATGAAAATATAGTGGTTTTATCTCAAGATAGCTGGGAAAGTTTACAAGAAACGATTC
GTTTGATGGAAAATGATTATCTATCACATAAGGTTATTAATGGTATATCACAAGTTAAAGAGAAGCAAGTCACTAAACAT
GGTTTAATTGAGGTAGAAGATGTTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References