Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 351597..352257 Replicon chromosome
Accession NZ_CP092004
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N14-1660

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MA620_RS01700 Protein ID WP_000244756.1
Coordinates 351597..352010 (-) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MA620_RS01705 Protein ID WP_000351186.1
Coordinates 351991..352257 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA620_RS01680 (347538) 347538..349271 - 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -
MA620_RS01685 (349277) 349277..349990 - 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MA620_RS01690 (350014) 350014..350910 - 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MA620_RS01695 (351023) 351023..351544 + 522 WP_001055885.1 flavodoxin FldB -
MA620_RS01700 (351597) 351597..352010 - 414 WP_000244756.1 protein YgfX Toxin
MA620_RS01705 (351991) 351991..352257 - 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MA620_RS01710 (352507) 352507..353487 + 981 WP_000874178.1 tRNA-modifying protein YgfZ -
MA620_RS01715 (353603) 353603..354262 - 660 WP_000250289.1 hemolysin III family protein -
MA620_RS01720 (354426) 354426..354737 - 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MA620_RS01725 (354895) 354895..356328 + 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T235426 WP_000244756.1 NZ_CP092004:c352010-351597 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T235426 NZ_LR134264:1704330-1704794 [Staphylococcus simulans]
ATGGGAGTTTACGAAGATTTATGTATCGCTAACGATTGGGTTGAAATTGAGGAGACCGATCGTTTACCTAGTTTCCAACC
AGGGTTTTACAGAAATGGAAAAATCTATATTAAAAGCAGTCTTTCTGAAACGCGCAAAGCTGAAGTTCTCTATGAAGAAT
TAGCTCACCATAAACTTACATACGGAAATATACTTGATGAATCAAGCTTTAATAACCGTAAATTTGAAAATTATGCACGA
AGACATGGTTATGAAAATGCTATATCTTTAACCAAGATTATAGATGCATATAAATACGGAGTAAGTAGCTTACATGAATT
TGCTGAATATGTTCAATTAAGCGAAGAATACGTATATACAGTGTTACAACATTATAAAAACAAATTCGGTTTATCAACCT
GCCACAATGGTTATCTTGTTCGTTTTGAGCCATTGCAGGTTTTTAAATATATAGAGAAAGAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT235426 WP_000351186.1 NZ_CP092004:c352257-351991 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235426 NZ_LR134264:1703985-1704317 [Staphylococcus simulans]
ATGAGAACAAATGATGAAATAATCACAATAATAAAAACAACGTTAAAAGAACAAAATATGTCGCTTAGTGAATTAGCTCG
TCGTGTAGGAATGGCTAAATCAGCTGTATCGCGTTATTTAAACTTAACTAGAGAGTTTCCATTGAACCGTGCGGAAGATT
TTGCAAAAGCACTTCATATTAGTACAGAATATTTACTTGGTTTTACAGAAAGTGAACAAAAAGAGCAAGAACAAGACACT
ATGGCCGCTCATTTTGACAAAGAAGGTCTAACAGAAGAGGAAATTGAAGAAGTTAATAAGTTTATTGAATGGGTTAAGAA
TAGAGATAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References