235421

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4124839..4125482 Replicon chromosome
Accession NZ_CP091999
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N16-1393

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag MA802_RS19930 Protein ID WP_000048134.1
Coordinates 4125066..4125482 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag MA802_RS19925 Protein ID WP_001261294.1
Coordinates 4124839..4125069 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA802_RS19915 (4121852) 4121852..4123990 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MA802_RS19920 (4124207) 4124207..4124671 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MA802_RS19925 (4124839) 4124839..4125069 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MA802_RS19930 (4125066) 4125066..4125482 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
MA802_RS19935 (4125543) 4125543..4127456 - 1914 WP_001212148.1 BglG family transcription antiterminator -
MA802_RS19940 (4127473) 4127473..4128213 - 741 WP_000779255.1 KDGP aldolase family protein -
MA802_RS19945 (4128210) 4128210..4129328 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MA802_RS19950 (4129312) 4129312..4130445 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T235421 WP_000048134.1 NZ_CP091999:4125066-4125482 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T235421 NZ_LR134263:865124-865345 [Staphylococcus delphini]
ATGGAAAATGGTTATGTTAAAGTAACACAACTGACAACTGAAGCACAGCAACAACAGCTATCTGATCGTTTGCTTCGTTT
AATTGGTGTCGAGAGTGTTGTTATTGATTTGGCAACACAATCGTTGACGCTCACTTATGACACGCCAGCAAATTTGAACA
CGATAGAAAAAGAAATTTATGATGCAGGATTTCCTGTTATCCAATCACATAAAGGAGTGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT235421 WP_001261294.1 NZ_CP091999:4124839-4125069 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT235421 NZ_LR134263:864824-865111 [Staphylococcus delphini]
ATGACTGAACAAGCACATCATTCTGAAGAAATTAAACGTAACTTGAAGTCGCGTTTGAATCGTATTGAAGGCCAAGTGAA
AGCAATCAACCGAATGATTGACGAAGATGTCTATTGTGATGACGTATTGACCCAAATTAGAGCGACACGTTCGGCTTTAA
ACAGTGTGGCGTCGCGTCTGTTAGATCATCATATGAAAGGTTGCATCATGCATAAGATTGACGCAGGGCACCAAGACGAA
GCGATGGAAGAGTTATTAGTAACGTTTCAAAAACTCATGAAAGATTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References