Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1001742..1002556 Replicon chromosome
Accession NZ_CP091999
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N16-1393

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag MA802_RS04830 Protein ID WP_000971653.1
Coordinates 1001742..1002269 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag MA802_RS04835 Protein ID WP_000855694.1
Coordinates 1002266..1002556 (-) Length 97 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA802_RS04800 (998116) 998116..998514 + 399 Protein_942 cytoplasmic protein -
MA802_RS04805 (998725) 998725..998943 + 219 Protein_943 hypothetical protein -
MA802_RS04810 (999100) 999100..999768 + 669 WP_000445914.1 hypothetical protein -
MA802_RS04815 (999795) 999795..1000289 + 495 WP_000424946.1 hypothetical protein -
MA802_RS04820 (1000461) 1000461..1001117 - 657 WP_023225036.1 protein-serine/threonine phosphatase -
MA802_RS04825 (1001467) 1001467..1001669 + 203 Protein_947 IS5/IS1182 family transposase -
MA802_RS04830 (1001742) 1001742..1002269 - 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
MA802_RS04835 (1002266) 1002266..1002556 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
MA802_RS04840 (1002827) 1002827..1003027 - 201 Protein_950 transposase -
MA802_RS04845 (1003268) 1003268..1003594 + 327 WP_000393295.1 hypothetical protein -
MA802_RS04850 (1003867) 1003867..1004214 - 348 WP_001555786.1 DUF1493 family protein -
MA802_RS04855 (1004199) 1004199..1004648 - 450 WP_023225038.1 hypothetical protein -
MA802_RS04860 (1005080) 1005080..1005523 - 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MA802_RS04865 (1005981) 1005981..1006631 + 651 WP_072203970.1 type III secretion system transcriptional activator InvF -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - invH / invF / invG / invE / invA / invB 1000461..1011944 11483
- inside IScluster/Tn - - 1001493..1003027 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

(1-95)


Sequences


Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T235407 WP_000971653.1 NZ_CP091999:c1002269-1001742 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T235407 NZ_LR134248:c834717-834343 [Escherichia coli]
ATGAACACATTACCCGACACACACGTACGGAAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTGTC
CCGACTACTGGGCCAGCATTACGGCCTTACACTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AAGCTGGCATTTCACTGTGTGACGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCACTTGTCCCCGCTCTCAGTTAATAAACAGTATTGATATCCTCCGGGCTCGCCGGGCGACCGGCCTGATGACCCGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGCATCCGGAGAAACGATGA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT235407 WP_000855694.1 NZ_CP091999:c1002556-1002266 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT235407 NZ_LR134248:c835175-834807 [Escherichia coli]
GTGTCAGACACATTCTCCGGGACAACTCATCCCGATGACAATCACGACCGTCCCTGGTGGGGACTACCCAGCACCGTGAC
GCCCTGTTTCGGGGCCCGTCTGGTGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGCGCCGGTATCAGAGGCCGGT
TCAGCGATGCGGATGCGAACCATCTGGACCAAGCCTTTCCGCTGCTGATGAAACAACTGGAACTCATGTTCACCAGCAGT
GAACTGAATCCCCACCGTCAGAATACCGTCACGCTGTATGCTAAAGGGCTGACCTGCCATGCGGACACCCTCGGCAGCTG
TGGTTACGTTTATCTTGCTGTTTATCCGACGCCCGAAACGAAACAGTAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8


Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References