Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 833667..834327 Replicon chromosome
Accession NZ_CP091999
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N16-1393

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MA802_RS04065 Protein ID WP_000244756.1
Coordinates 833914..834327 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MA802_RS04060 Protein ID WP_000351186.1
Coordinates 833667..833933 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA802_RS04040 (829596) 829596..831029 - 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -
MA802_RS04045 (831187) 831187..831498 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MA802_RS04050 (831662) 831662..832321 + 660 WP_000250289.1 hemolysin III family protein -
MA802_RS04055 (832437) 832437..833417 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
MA802_RS04060 (833667) 833667..833933 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MA802_RS04065 (833914) 833914..834327 + 414 WP_000244756.1 protein YgfX Toxin
MA802_RS04070 (834380) 834380..834901 - 522 WP_001055885.1 flavodoxin FldB -
MA802_RS04075 (835014) 835014..835910 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MA802_RS04080 (835934) 835934..836647 + 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MA802_RS04085 (836653) 836653..838386 + 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T235406 WP_000244756.1 NZ_CP091999:833914-834327 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T235406 NZ_LR134248:741378-741674 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCACTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT235406 WP_000351186.1 NZ_CP091999:833667-833933 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235406 NZ_LR134248:741676-742071 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References