Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4726471..4727114 Replicon chromosome
Accession NZ_CP091998
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N18-2092

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag MA840_RS22950 Protein ID WP_000048134.1
Coordinates 4726698..4727114 (+) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag MA840_RS22945 Protein ID WP_001261294.1
Coordinates 4726471..4726701 (+) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA840_RS22935 (4723484) 4723484..4725622 + 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -
MA840_RS22940 (4725839) 4725839..4726303 + 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MA840_RS22945 (4726471) 4726471..4726701 + 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MA840_RS22950 (4726698) 4726698..4727114 + 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
MA840_RS22955 (4727175) 4727175..4729088 - 1914 WP_001212148.1 BglG family transcription antiterminator -
MA840_RS22960 (4729105) 4729105..4729845 - 741 WP_000779255.1 KDGP aldolase family protein -
MA840_RS22965 (4729842) 4729842..4730960 - 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MA840_RS22970 (4730944) 4730944..4732077 - 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T235403 WP_000048134.1 NZ_CP091998:4726698-4727114 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T235403 NZ_LR134248:214032-214139 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGTATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT235403 WP_001261294.1 NZ_CP091998:4726471-4726701 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT235403 NZ_LR134248:c213974-213918 [Escherichia coli]
CAAGAATGGCCCCCGTGGTGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References