Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3457155..3457775 Replicon chromosome
Accession NZ_CP091998
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N18-2092

Toxin (Protein)


Gene name Hha Uniprot ID V1H8E6
Locus tag MA840_RS16995 Protein ID WP_001280991.1
Coordinates 3457557..3457775 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V1H4V6
Locus tag MA840_RS16990 Protein ID WP_000344807.1
Coordinates 3457155..3457529 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA840_RS16980 (3452294) 3452294..3453487 + 1194 WP_001039199.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
MA840_RS16985 (3453510) 3453510..3456659 + 3150 WP_001132508.1 efflux RND transporter permease AcrB -
MA840_RS16990 (3457155) 3457155..3457529 + 375 WP_000344807.1 Hha toxicity modulator TomB Antitoxin
MA840_RS16995 (3457557) 3457557..3457775 + 219 WP_001280991.1 HHA domain-containing protein Toxin
MA840_RS17000 (3457954) 3457954..3458505 + 552 WP_001278793.1 maltose O-acetyltransferase -
MA840_RS17005 (3458623) 3458623..3459093 + 471 WP_000136183.1 YlaC family protein -
MA840_RS17010 (3459149) 3459149..3459289 - 141 WP_001197749.1 type B 50S ribosomal protein L36 -
MA840_RS17015 (3459295) 3459295..3459555 - 261 WP_000801415.1 type B 50S ribosomal protein L31 -
MA840_RS17020 (3459780) 3459780..3461330 + 1551 WP_000213145.1 EAL domain-containing protein -
MA840_RS17030 (3461561) 3461561..3461950 + 390 WP_023224410.1 MGMT family protein -
MA840_RS17035 (3461983) 3461983..3462552 - 570 WP_000779802.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-116)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8613.97 Da        Isoelectric Point: 8.9008

>T235397 WP_001280991.1 NZ_CP091998:3457557-3457775 [Salmonella enterica subsp. enterica serovar Kentucky]
MSDKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

>T235397 NZ_LR134247:3696347-3696565 [Escherichia coli]
ATGTCCGAAAAACCTTTAACGAAAACCGATTATTTAATGCGTTTACGTCGTTGCCAGACAATTGACACGCTGGAGCGTGT
TATCGAGAAAAATAAATACGAATTATCAGATAATGAACTGGCGGTATTTTACTCAGCCGCAGATCACCGCCTCGCCGAAT
TGACCATGAATAAACTGTACGACAAGATCCCTTCCTCAGTATGGAAATTTATTCGCTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14453.27 Da        Isoelectric Point: 5.1444

>AT235397 WP_000344807.1 NZ_CP091998:3457155-3457529 [Salmonella enterica subsp. enterica serovar Kentucky]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAVNLQLNELIEHIATFALNYKIKYNEDNKLIAQIDEYL
DDTFMLFSSYGINTQDLQKWRKSGNRLFRCFVNATRANPVSLSC

Download         Length: 375 bp

>AT235397 NZ_LR134247:3695947-3696321 [Escherichia coli]
ATGGATGAATACTCACCCAAAAGACATGATATCGCACAGCTTAAGTTTCTCTGTGAAACCCTGTATCATGACTGCCTTGC
AAACCTTGAAGAAAGCAATCATGGCTGGGTAAACGACCCAACCTCGGCGATCAACCTCCAGTTGAATGAACTGATTGAGC
ATATTGCGACCTTCGCACTTAATTACAAAATTAAGTATAATGAAGACAATAAGCTCATTGAGCAGATCGACGAATATCTG
GATGACACCTTTATGTTGTTCAGTAGTTATGGTATTAATATGCAGGATCTTCAGAAATGGCGGAAGTCAGGTAATCGACT
ATTCCGTTGTTTTGTCAATGCGACGAAAGAGAATCCTGCGAGTTTATCTTGTTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 4ICG

Antitoxin

Source ID Structure
AlphaFold DB A0A5I5FGI0

References