235396

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbDE/ParE-YafN
Location 2466177..2466699 Replicon chromosome
Accession NZ_CP091998
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N18-2092

Toxin (Protein)


Gene name stbE Uniprot ID V7IL40
Locus tag MA840_RS12120 Protein ID WP_000221345.1
Coordinates 2466415..2466699 (+) Length 95 a.a.

Antitoxin (Protein)


Gene name stbD Uniprot ID V1H457
Locus tag MA840_RS12115 Protein ID WP_000885424.1
Coordinates 2466177..2466425 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA840_RS12085 (2461706) 2461706..2462611 - 906 WP_102603908.1 nitronate monooxygenase -
MA840_RS12090 (2463013) 2463013..2463201 + 189 WP_001276021.1 DUF29 family protein -
MA840_RS12095 (2463567) 2463567..2464306 + 740 Protein_2372 hypothetical protein -
MA840_RS12100 (2464308) 2464308..2465216 - 909 WP_077906523.1 hypothetical protein -
MA840_RS12105 (2465489) 2465489..2465820 - 332 Protein_2374 DUF1493 family protein -
MA840_RS12110 (2465906) 2465906..2466025 - 120 Protein_2375 type II and III secretion system -
MA840_RS12115 (2466177) 2466177..2466425 + 249 WP_000885424.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
MA840_RS12120 (2466415) 2466415..2466699 + 285 WP_000221345.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
MA840_RS12125 (2466870) 2466870..2467259 + 390 WP_000194089.1 RidA family protein -
MA840_RS12130 (2467311) 2467311..2468390 - 1080 WP_023203126.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
MA840_RS12135 (2468583) 2468583..2469071 - 489 WP_023223899.1 MarR family winged helix-turn-helix transcriptional regulator -
MA840_RS12140 (2469116) 2469116..2470624 + 1509 WP_023223898.1 FAD-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-84)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11043.79 Da        Isoelectric Point: 10.6500

>T235396 WP_000221345.1 NZ_CP091998:2466415-2466699 [Salmonella enterica subsp. enterica serovar Kentucky]
MTYKLAFNESALKEWKKLGHTIQEQFKKKLRERLENPRVPASQLHGRKDQYKIKLRGAGYRLVYSVEDEIITVTVIGVGK
RENDAVYKVTRHRS

Download         Length: 285 bp

>T235396 NZ_LR134247:c2900059-2899956 [Escherichia coli]
GGCAAGGCAACTAAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATAC
AGGAATCGTGTTCGGTCTCTTTTT

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9090.32 Da        Isoelectric Point: 3.9820

>AT235396 WP_000885424.1 NZ_CP091998:2466177-2466425 [Salmonella enterica subsp. enterica serovar Kentucky]
MAFQILTTTAASITELKRDPMGTFNAGDGAPVAILNRNEPAFYCVPPALYAHLMDILEDEELGRIIDERANERVIEVNID
DL

Download         Length: 249 bp

>AT235396 NZ_LR134247:2899918-2900189 [Escherichia coli]
AAAGTCAGCGAAGGAAATGCTTCTGGCTTTTAACAGATAAAAAGAGACCGAACACGATTCCTGTATTCGGTCCAGGGAAA
TGGCTCTTGGGAGAGAGCCGTGCGCTAAAAGTTGGCATTAATGCAGGCTTAGTTGCCTTGCCCTTTAAGAATAGATGACG
ACGCCAGGTTTTCCAGTTTGCGTGCAAAATGGTCAATAAAAAGCGTGGTGGTCATCAGCTGAAATGTTAAAAACCGCCCG
TTCTGGTGAAAGAACTGAGGCGGTTTTTTTAT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5Y2FFA8

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0WPN5

References