Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1072741..1073555 Replicon chromosome
Accession NZ_CP091998
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N18-2092

Toxin (Protein)


Gene name TacT3 Uniprot ID A0A3G3DUX8
Locus tag MA840_RS05310 Protein ID WP_000971653.1
Coordinates 1072741..1073268 (-) Length 176 a.a.

Antitoxin (Protein)


Gene name TacA3 Uniprot ID M7S6I2
Locus tag MA840_RS05315 Protein ID WP_000855694.1
Coordinates 1073265..1073555 (-) Length 97 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA840_RS05280 (1069115) 1069115..1069513 + 399 Protein_1038 cytoplasmic protein -
MA840_RS05285 (1069724) 1069724..1069942 + 219 Protein_1039 hypothetical protein -
MA840_RS05290 (1070099) 1070099..1070767 + 669 WP_000445914.1 hypothetical protein -
MA840_RS05295 (1070794) 1070794..1071288 + 495 WP_000424946.1 hypothetical protein -
MA840_RS05300 (1071460) 1071460..1072116 - 657 WP_023225036.1 protein-serine/threonine phosphatase -
MA840_RS05305 (1072466) 1072466..1072668 + 203 Protein_1043 IS5/IS1182 family transposase -
MA840_RS05310 (1072741) 1072741..1073268 - 528 WP_000971653.1 GNAT family N-acetyltransferase Toxin
MA840_RS05315 (1073265) 1073265..1073555 - 291 WP_000855694.1 DUF1778 domain-containing protein Antitoxin
MA840_RS05320 (1073826) 1073826..1074026 - 201 Protein_1046 transposase -
MA840_RS05325 (1074267) 1074267..1074593 + 327 WP_000393295.1 hypothetical protein -
MA840_RS05330 (1074866) 1074866..1075213 - 348 WP_001555786.1 DUF1493 family protein -
MA840_RS05335 (1075198) 1075198..1075647 - 450 WP_023225038.1 hypothetical protein -
MA840_RS05340 (1076079) 1076079..1076522 - 444 WP_023225039.1 SPI-1 type III secretion system invasion lipoprotein InvH -
MA840_RS05345 (1076980) 1076980..1077630 + 651 WP_072203970.1 type III secretion system transcriptional activator InvF -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside IScluster/Tn - - 1072492..1074026 1534


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Vibrio phage ICP1, Orf50

(1-95)


Sequences

Toxin        


Download         Length: 176 a.a.        Molecular weight: 19043.87 Da        Isoelectric Point: 9.7032

>T235387 WP_000971653.1 NZ_CP091998:c1073268-1072741 [Salmonella enterica subsp. enterica serovar Kentucky]
MMFTDWHEAAIGKTHNRMNFDCGDADLNQFLQRHARQNHEKGTTKTYVALDNSDVTRIHGFYSVSPASLIYAQVPGAISK
GLGRHDVPVFRLGRLAVDKSMQGQGLGAQLLLSAGKRCIQAALQVGGVALLIDAKNKQVCDWYKGFGAVPLNDQPLSLLL
SFKTLYAALSASGRL

Download         Length: 528 bp

>T235387 NZ_LR134247:c2036402-2036295 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGATTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGAATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin


Download         Length: 97 a.a.        Molecular weight: 10664.50 Da        Isoelectric Point: 6.3133

>AT235387 WP_000855694.1 NZ_CP091998:c1073555-1073265 [Salmonella enterica subsp. enterica serovar Kentucky]
MKTMPQIAIESNERLSLRVSTDAKKLIVRAAAIQQTNLTDFVVSNVLPVAQKIVDAAERVYLTERDTQMIMEILDNPPAP
NEKLLAAAFALPDMKK

Download         Length: 291 bp

>AT235387 NZ_LR134247:2036450-2036516 [Escherichia coli]
GTTCTGGTTCAAGATTAGCCCCCGTTCTGTTGTCAGGTTGTACCTCTCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3G3DUX8

Antitoxin

Source ID Structure
AlphaFold DB A0A3V8SJE7

References