Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 863989..864649 Replicon chromosome
Accession NZ_CP091998
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N18-2092

Toxin (Protein)


Gene name cptA Uniprot ID Q57K70
Locus tag MA840_RS04265 Protein ID WP_000244756.1
Coordinates 864236..864649 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S5MU13
Locus tag MA840_RS04260 Protein ID WP_000351186.1
Coordinates 863989..864255 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA840_RS04240 (859918) 859918..861351 - 1434 WP_001230143.1 6-phospho-beta-glucosidase BglA -
MA840_RS04245 (861509) 861509..861820 + 312 WP_001182976.1 N(4)-acetylcytidine aminohydrolase -
MA840_RS04250 (861984) 861984..862643 + 660 WP_000250289.1 hemolysin III family protein -
MA840_RS04255 (862759) 862759..863739 - 981 WP_000874178.1 tRNA-modifying protein YgfZ -
MA840_RS04260 (863989) 863989..864255 + 267 WP_000351186.1 FAD assembly factor SdhE Antitoxin
MA840_RS04265 (864236) 864236..864649 + 414 WP_000244756.1 protein YgfX Toxin
MA840_RS04270 (864702) 864702..865223 - 522 WP_001055885.1 flavodoxin FldB -
MA840_RS04275 (865336) 865336..866232 + 897 WP_000434302.1 site-specific tyrosine recombinase XerD -
MA840_RS04280 (866256) 866256..866969 + 714 WP_023223829.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
MA840_RS04285 (866975) 866975..868708 + 1734 WP_023223830.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 16183.15 Da        Isoelectric Point: 10.7537

>T235386 WP_000244756.1 NZ_CP091998:864236-864649 [Salmonella enterica subsp. enterica serovar Kentucky]
VVLWQSDLRVSWRAQWISLLIHGLVAAVILLMPWPLSYTPLWMILLSLVVFDCVRSQRRINTCQGEIKLLMDGRLRWQGQ
DWTLLRPPWLLKSGMVLRLRAESGRHQHLWLAADSMEEAEWRELRRILLQQPISGQH

Download         Length: 414 bp

>T235386 NZ_LR134247:c1858264-1857887 [Escherichia coli]
ATGAAAACATTACCCGACACGCATGTACGGGAGGTATCGTGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGGTTACTGGACCAGCATTACAGCCTTACGCTGAATGACACACCGTTCGTGGATGAACGCGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCAGTGAACTTTCTCGTGGAAAAATACGCACTGGTACGAACTGACCAGCCGGGATTC
AGCGCAGGAGCCTCGTCGCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCCGGGCAACAGGCCTGATGACCCGCCA
CAACTACAGAACGGTGAACAATATCACCCTGGGTAAGTATCCGGAGGCGAAACGATGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10550.05 Da        Isoelectric Point: 6.0783

>AT235386 WP_000351186.1 NZ_CP091998:863989-864255 [Salmonella enterica subsp. enterica serovar Kentucky]
MDIHNKARIHWACRRGMRELDISIMPFFEHEYDSLSDEEKRIFVRLLQSDDPDLFNWLMNHGKPADAELEQMVRLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT235386 NZ_LR134247:c1858722-1858354 [Escherichia coli]
GTGTCAGACACACTTTCCGGGACAACGCATCCCGATGACAATGACGACCATCCCTGGTGGGGACTACCCTGCACAGTGAC
GCCCTGTTTCGGCGCCCGTCTGGAGCAGGAGGGTAACCGGTTGCATTACCTTGCCGACCGTGCCGGTATCAGAGGCCGGT
TCAGAGATGCGGATGCGTACCCTCTGGACCAGGCCTTTCCGCTGCTGATGAAACAACTGAAATTAATGCTCACCAGTGGT
GAACTGAATCCCCGCCATCAGCATACCGTGACACTGTATGCGAAGGGGCTGACCTGTGAAGCCGACACCCTCGGCTCCTG
TGGTTACGTTTATCTGGCTGTTTATCCGACACCTGAAACGAAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A3Z1E9V5

Antitoxin

Source ID Structure
AlphaFold DB A0A5I0YWH4

References