235383

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vagCD/VapC-VagC
Location 4667875..4668518 Replicon chromosome
Accession NZ_CP091997
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N20-2289

Toxin (Protein)


Gene name vagD Uniprot ID B5F3H8
Locus tag MA641_RS22660 Protein ID WP_000048134.1
Coordinates 4667875..4668291 (-) Length 139 a.a.

Antitoxin (Protein)


Gene name vagC Uniprot ID B5F3H9
Locus tag MA641_RS22665 Protein ID WP_001261294.1
Coordinates 4668288..4668518 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA641_RS22640 (4662912) 4662912..4664045 + 1134 WP_023224151.1 amidohydrolase/deacetylase family metallohydrolase -
MA641_RS22645 (4664029) 4664029..4665147 + 1119 WP_023224150.1 DgaE family pyridoxal phosphate-dependent ammonia lyase -
MA641_RS22650 (4665144) 4665144..4665884 + 741 WP_000779255.1 KDGP aldolase family protein -
MA641_RS22655 (4665901) 4665901..4667814 + 1914 WP_001212148.1 BglG family transcription antiterminator -
MA641_RS22660 (4667875) 4667875..4668291 - 417 WP_000048134.1 type II toxin-antitoxin system VapC family toxin Toxin
MA641_RS22665 (4668288) 4668288..4668518 - 231 WP_001261294.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
MA641_RS22670 (4668686) 4668686..4669150 - 465 WP_001009178.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
MA641_RS22675 (4669367) 4669367..4671505 - 2139 WP_000187821.1 anaerobic ribonucleoside-triphosphate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-129)

Antitoxin

SpoVT-AbrB domain

(7-44)


Sequences

Toxin        


Download         Length: 139 a.a.        Molecular weight: 15135.50 Da        Isoelectric Point: 8.1381

>T235383 WP_000048134.1 NZ_CP091997:c4668291-4667875 [Salmonella enterica subsp. enterica serovar Kentucky]
MSKTYMLDTCICSFIMREQPEAVLKRLEQAVLRRHRIVVSAITYAEMRFGCTGKKASPRHAQLVDAFCSRLDAVLAWDRA
AVDATTEIRAVLAAAGTPIGSNDAAIAGHAIASGAILVTNNVREFERVPGLQYEDWVK

Download         Length: 417 bp

>T235383 NZ_LR134247:752758-753054 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8878.90 Da        Isoelectric Point: 4.6677

>AT235383 WP_001261294.1 NZ_CP091997:c4668518-4668288 [Salmonella enterica subsp. enterica serovar Kentucky]
MRTVSVFKNGNNRAIRLPRDLDFDGVNELEIFREGDTIILRPARPSWGSFRHEEKASPDFLTEREDIISDEGRFEL

Download         Length: 231 bp

>AT235383 NZ_LR134247:753056-753451 [Escherichia coli]
ATGAAATGTCCGGTTTGCCACCAGGGAGAAATGGTTTCTGGCATTAAAGATATTCCATACACCTTCCGTGGACGAAAAAC
AGTATTGAAAGGTATCCACGGTTTATATTGTGTCCATTGCGAAGAGAGCATCATGAATAAAGAAGAGTCAGATGCTTTCA
TGGCGCAAGTAAAGGCATTTCGGGCTTCGGTGAATGCCGAAACAGTGGCACCTGAATTTATAGTGAAGGTTCGAAAAAAG
CTCTCTCTTACCCAAAAAGAGGCAAGCGAAATTTTTGGGGGAGGTGTAAATGCGTTTTCGCGTTACGAAAAAGGCAATGC
CCAACCTCATCCTTCCACAATCAAACTTTTACGTGTTCTGGATAAGCATCCAGAACTATTGAATGAAATCCGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A2T8L749

Antitoxin

Source ID Structure
AlphaFold DB A0A3V4SIC2

References