Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-dinJ/YafQ-RelB
Location 2303738..2304269 Replicon chromosome
Accession NC_011992
Organism Acidovorax ebreus TPSY

Toxin (Protein)


Gene name relE Uniprot ID A0A1L1PPY2
Locus tag DTPSY_RS10815 Protein ID WP_015913622.1
Coordinates 2303738..2304019 (-) Length 94 a.a.

Antitoxin (Protein)


Gene name dinJ Uniprot ID A0A1L1PSE5
Locus tag DTPSY_RS10820 Protein ID WP_015913623.1
Coordinates 2304006..2304269 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
DTPSY_RS10795 2299187..2301361 - 2175 WP_015913618.1 copper-translocating P-type ATPase -
DTPSY_RS10800 2301499..2301783 + 285 WP_015913619.1 hypothetical protein -
DTPSY_RS10805 2301850..2302353 + 504 WP_015913620.1 MerR family transcriptional regulator -
DTPSY_RS10810 2302350..2302823 + 474 WP_015913621.1 hypothetical protein -
DTPSY_RS10815 2303738..2304019 - 282 WP_015913622.1 type II toxin-antitoxin system YafQ family toxin Toxin
DTPSY_RS10820 2304006..2304269 - 264 WP_015913623.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
DTPSY_RS10825 2304442..2304881 + 440 Protein_2169 antirestriction protein -
DTPSY_RS10830 2304927..2305145 + 219 WP_015913624.1 hypothetical protein -
DTPSY_RS10835 2305156..2306343 + 1188 WP_015913625.1 hypothetical protein -
DTPSY_RS10840 2306360..2306617 + 258 WP_015913626.1 hypothetical protein -
DTPSY_RS10845 2306775..2307011 + 237 WP_015913627.1 stable inheritance protein KleA -
DTPSY_RS18145 2307103..2307516 - 414 Protein_2174 hypothetical protein -
DTPSY_RS10850 2307518..2308726 - 1209 Protein_2175 ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, YafQ-like toxin

(2-91)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-84)


Sequences

Toxin        


Download         Length: 94 a.a.        Molecular weight: 10715.18 Da        Isoelectric Point: 8.1258

>T23538 WP_015913622.1 NC_011992:c2304019-2303738 [Acidovorax ebreus TPSY]
MRQIERTGQFKRDYKREAKGQHRATLDADLVPVLVALASDQPLEPRHRDHALTGDWKDHRDCHVKPDLVLIYQKPDADTL
RLVRIGSHSELGL

Download         Length: 282 bp

>T23538 NC_011992:c2304019-2303738 [Acidovorax ebreus TPSY]
ATGCGGCAGATTGAGCGCACCGGCCAGTTCAAGCGCGACTACAAGCGCGAGGCGAAGGGGCAGCACCGGGCCACGCTCGA
TGCCGACCTGGTGCCTGTCCTGGTCGCGCTGGCCTCCGATCAACCGCTGGAACCTCGGCACCGCGACCACGCGCTGACCG
GGGACTGGAAAGATCACCGGGATTGCCACGTCAAGCCCGACCTGGTGCTGATCTACCAGAAGCCCGACGCCGACACGCTG
CGCCTGGTGCGCATCGGCTCTCACTCCGAACTCGGCTTGTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 9212.80 Da        Isoelectric Point: 5.7905

>AT23538 WP_015913623.1 NC_011992:c2304269-2304006 [Acidovorax ebreus TPSY]
MAANQLVQTRIDGAIKEEAAAVLAAMGLTVSDAVRLLLTKVAQDKALPFEPLIPNATTIEAMKEARKGKLPRFATVDALM
ADLHAAD

Download         Length: 264 bp

>AT23538 NC_011992:c2304269-2304006 [Acidovorax ebreus TPSY]
ATGGCTGCAAACCAGCTCGTACAAACGCGCATCGACGGCGCGATCAAGGAAGAAGCGGCGGCCGTCTTGGCCGCGATGGG
CCTTACCGTGTCCGACGCGGTGCGGCTGCTGCTCACGAAGGTTGCCCAGGACAAGGCGCTGCCCTTCGAGCCGCTGATTC
CGAACGCCACCACCATCGAGGCGATGAAGGAAGCCCGCAAGGGCAAGCTGCCGCGCTTCGCCACCGTGGACGCTCTGATG
GCCGATCTGCATGCGGCAGATTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1L1PPY2

Antitoxin

Source ID Structure
AlphaFold DB A0A1L1PSE5

References