235379

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 3729944..3730735 Replicon chromosome
Accession NZ_CP091997
Organism Salmonella enterica subsp. enterica serovar Kentucky strain N20-2289

Toxin (Protein)


Gene name ataT Uniprot ID C0Q119
Locus tag MA641_RS18295 Protein ID WP_000369560.1
Coordinates 3729944..3730462 (-) Length 173 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID Q57IR1
Locus tag MA641_RS18300 Protein ID WP_001275017.1
Coordinates 3730466..3730735 (-) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MA641_RS18270 (3725009) 3725009..3725776 - 768 WP_000082083.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
MA641_RS18275 (3725773) 3725773..3727050 - 1278 WP_000803766.1 branched chain amino acid ABC transporter permease LivM -
MA641_RS18280 (3727047) 3727047..3727973 - 927 WP_000003005.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
MA641_RS18285 (3728033) 3728033..3729142 - 1110 WP_023224165.1 high-affinity branched-chain amino acid ABC transporter substrate-binding protein LivK -
MA641_RS18290 (3729564) 3729564..3729947 + 384 WP_000778873.1 aspartate 1-decarboxylase autocleavage activator PanM -
MA641_RS18295 (3729944) 3729944..3730462 - 519 WP_000369560.1 GNAT family N-acetyltransferase Toxin
MA641_RS18300 (3730466) 3730466..3730735 - 270 WP_001275017.1 DUF1778 domain-containing protein Antitoxin
MA641_RS18305 (3730913) 3730913..3732016 - 1104 WP_001533929.1 branched chain amino acid ABC transporter substrate-binding protein LivJ -
MA641_RS18310 (3732338) 3732338..3733192 - 855 WP_000159621.1 RNA polymerase sigma factor RpoH -
MA641_RS18315 (3733438) 3733438..3734493 - 1056 WP_001081707.1 permease-like cell division protein FtsX -
MA641_RS18320 (3734486) 3734486..3735154 - 669 WP_000617729.1 cell division ATP-binding protein FtsE -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(90-150)

Antitoxin

Vibrio phage ICP1, Orf50

(8-86)


Sequences

Toxin        


Download         Length: 173 a.a.        Molecular weight: 19414.16 Da        Isoelectric Point: 8.9619

>T235379 WP_000369560.1 NZ_CP091997:c3730462-3729944 [Salmonella enterica subsp. enterica serovar Kentucky]
VDNLTIEILADNAEYNWRQFDCGEASLNLFLTQHLQRQHNNKILRGYVLRTTTPERRVLGYYTLSGSCFERASLPSRTQQ
KRIPYQNIPSVTLGRLAVDLSLQGKGWGAILVTHAMKVVWSASLAVGIHGIFVEALNEKAQAFYQRLGFISLSGENEHAL
FYPTKSIEQLFG

Download         Length: 519 bp

>T235379 NZ_LR134244:959427-959606 [Staphylococcus warneri]
ATGACTCAAAATAAAGATTCTAAAACGAATTACCACGAAGAAGAAAATGCAATGGTAACCGATTTAGATGATTTAAAAGA
CTTAGGAAAAGAAATGGAACAAATTTCTGAAGAAAATGATGAAGAAAAATTAAATCAATCTCATGATTCAGATGTTCGTT
CTGATTTAGATCAAGATTAA

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 10086.53 Da        Isoelectric Point: 7.2056

>AT235379 WP_001275017.1 NZ_CP091997:c3730735-3730466 [Salmonella enterica subsp. enterica serovar Kentucky]
MSALKKQRIDLRLTDGDKSMIEEAAAITNQSITQFMLNSAAERAAEVLEQHRRVILNEASWARVMDALSHPPTPNEKLKR
AAQRLQDME

Download         Length: 270 bp

>AT235379 NZ_LR134244:958800-959399 [Staphylococcus warneri]
ATGGCAATGAACTTTAAAGTATTTGAAGATAAACAAAGAGTAGCTGAATATACAGCAGACATTTTGAGAAAACAATTTAA
TAACAACCCAATGACAATCGCAGGTGTTCATTTAACAAAAGATCATGCACCTGTATTAGATGAATTAAAAAAGAATGTTG
ATTTACATGCAGTTGATTTCAGTCAAATTAATATTTTAGATTATGATGAAAATCAATCATATTATGAAGCGTTAGGTGTA
CCACAAAGCCAAATTTATTCATTATCATACAACCAAGATGCTAATGACTTTATTTCAGATAAAATTAAAACAAAGGAAAA
TAAAGGTAAATTAGTCTTACAAGTTGTTTCAATTGATGAAAATGGTAATTTAGATGTAAGTGTAAGACAAGGGTTATTAG
AAGCACGCGAAATCTTCTTAGTTGTTACTGGTAGTAATAAACGTGAAGTAGTCGAAAAATTATATAACGAAAATGGAAAA
TCTAATTTTGAACCTGCAGACTTAAAAGTGCACCGTATGGTTAACGTTATTTTAGATAAAGAAGCAGCAGCTGGATTACC
TGAAGACGTGAAAGAATACTTCACAGCTCGCTTTGCATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A5H5BA59

Antitoxin

Source ID Structure
AlphaFold DB A0A5I8URP5

References